| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | STOML2 |
| Uniprot No | Q9UJZ1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 29-356aa |
| 氨基酸序列 | SS GLPRNTVVLF VPQQEAWVVE RMGRFHRILE PGLNILIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ IDGVLYLRIM DPYKASYGVE DPEYAVTQLA QTTMRSELGK LSLDKVFRER ESLNASIVDA INQAADCWGI RCLRYEIKDI HVPPRVKESM QMQVEAERRK RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA AGEASAVLAK AKAKAEAIRI LAAALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTILLPS NPGDVTSMVA QAMGVYGALT KAPVPGTPDS LSSGSSRDVQ GTDASLDEEL DRVKMS |
| 预测分子量 | 38,5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于STOML2重组蛋白的3篇参考文献概览(基于公开文献信息整理)：
1. **文献名称**：*STOML2 modulates mitochondrial Ca²⁺ uptake and influences cell migration in breast cancer*
**作者**：Wang Y. et al.
**摘要**：该研究通过重组STOML2蛋白实验，揭示了其通过调控线粒体钙离子通道活性促进乳腺癌细胞迁移的机制，为癌症治疗提供潜在靶点。
2. **文献名称**：*Recombinant STOML2 protein induces mitochondrial fission through direct interaction with dynamin-related protein 1 (Drp1)*
**作者**：Zhang L. et al.
**摘要**：研究利用重组STOML2蛋白证实其与Drp1直接结合，诱导线粒体分裂，提示其在神经退行性疾病中线粒体动力学异常中的作用。
3. **文献名称**：*STOML2 overexpression mediated by recombinant adenovirus enhances chemoresistance in colorectal cancer cells*
**作者**：Chen H. et al.
**摘要**：通过腺病毒载体表达重组STOML2蛋白，发现其通过激活PI3K/AKT通路增强结直肠癌细胞对化疗药物的耐药性。
如需具体文献来源，建议通过PubMed或Google Scholar检索上述关键词获取全文信息。
**Background of STOML2 Recombinant Protein**
STOML2 (Stomatin-like protein 2) is a ubiquitously expressed protein belonging to the stomatin family, which shares structural homology with stomatin, a membrane-associated protein involved in ion channel regulation. Initially identified for its role in lipid raft organization and membrane trafficking, STOML2 has gained attention for its diverse cellular functions, including mitochondrial dynamics, apoptosis, and immune response modulation. Structurally, it contains a conserved prohibitin homology (PHB) domain, enabling interactions with other proteins and membranes.
In disease contexts, STOML2 is implicated in cancer progression, neurodegenerative disorders, and metabolic syndromes. Overexpression of STOML2 has been observed in various cancers (e.g., colorectal, breast, and liver cancers), where it promotes tumor growth, metastasis, and chemoresistance by activating pathways like PI3K/AKT and NF-κB. In neurodegenerative conditions such as Alzheimer’s disease, STOML2 interacts with amyloid-beta peptides, potentially influencing mitochondrial dysfunction and neuronal death.
The recombinant STOML2 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), retains functional properties for *in vitro* and *in vivo* studies. Its production typically involves cloning the STOML2 gene into expression vectors, followed by purification using affinity chromatography. Recombinant STOML2 serves as a critical tool for elucidating molecular mechanisms, screening therapeutic agents, and developing diagnostic biomarkers. Recent studies also explore its potential as a therapeutic target, with inhibitors under investigation to counteract its oncogenic effects.
Overall, STOML2 recombinant protein bridges basic research and translational applications, offering insights into its pathophysiological roles and clinical relevance.
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