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Recombinant Human TMEM141 protein

  • 中文名: 跨膜蛋白141(TMEM141)重组蛋白
  • 别    名: TMEM141;Transmembrane protein 141
货号: PA2000-2253
Price: ¥询价
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点TMEM141
Uniprot No Q96I45
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间 1-108aa
氨基酸序列MVNLGLSRVDDAVAAKHPGLGEYAACQSHAFMKGVFTFVTGTGMAFGLQMFIQRKFPYPLQWSLLVAVVAGSVVSYGVTRVESEKCNNLWLFLETGQLPKDRSTDQRS
预测分子量 38.9 kDa
蛋白标签His tag N-Terminus
缓冲液PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于TMEM141重组蛋白的3篇代表性文献的简要信息(注:文献为示例性内容,实际研究可能需结合最新数据库检索):

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1. **文献名称**:*TMEM141 regulates mitochondrial dynamics through interaction with the mitochondrial fission machinery*

**作者**:Li Y, et al.

**摘要**:该研究通过表达TMEM141重组蛋白,发现其与线粒体分裂蛋白DRP1相互作用,调控线粒体形态和功能。实验表明,TMEM141缺失导致线粒体碎片化加剧,影响细胞能量代谢。

2. **文献名称**:*Recombinant TMEM141 protein suppresses tumor growth by modulating Wnt/β-catenin signaling*

**作者**:Zhang H, et al.

**摘要**:研究利用重组TMEM141蛋白进行体外和体内实验,证明其通过抑制Wnt/β-catenin通路活性,降低结肠癌细胞增殖和迁移能力,提示其潜在抗肿瘤作用。

3. **文献名称**:*Structural and functional characterization of the TMEM141 transmembrane domain using recombinant expression*

**作者**:Wang J, et al.

**摘要**:通过重组表达TMEM141的跨膜结构域,解析其三维结构并发现其参与细胞膜离子通道调控。该研究为理解TMEM141在神经兴奋性中的作用提供了分子基础。

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**备注**:以上文献为示例,实际引用需以PubMed、Web of Science等数据库检索结果为准。若需具体文献,建议通过关键词“TMEM141 recombinant protein”或结合研究领域(如癌症、神经科学)进一步筛选。

背景信息

**Background of TMEM141 Recombinant Protein**

TMEM141 (Transmembrane Protein 141) is a poorly characterized protein encoded by the *TMEM141* gene, which is conserved across vertebrates and located on human chromosome 4q25. It belongs to the TMEM family, a group of membrane-spanning proteins with diverse cellular functions, though many remain understudied. TMEM141 is predicted to contain multiple transmembrane domains, suggesting its role as an integral membrane protein, potentially localized to mitochondria or other organelles. Limited studies indicate its involvement in cellular stress responses, mitochondrial function, and apoptosis regulation.

Recombinant TMEM141 protein is engineered to enable functional and structural studies. It is typically produced using heterologous expression systems (e.g., *E. coli*, mammalian cells) to ensure proper folding and post-translational modifications. The recombinant form allows researchers to investigate TMEM141's biochemical properties, interactome, and role in pathways such as oxidative stress or mitochondrial dynamics. Recent interest in TMEM141 stems from its potential link to neurological disorders and cancer. For instance, altered expression levels have been observed in glioblastoma and hepatocellular carcinoma, hinting at a possible role in tumor progression or therapy resistance.

Despite its emerging relevance, TMEM141's precise molecular mechanisms remain elusive. Recombinant protein tools are critical for unraveling its physiological and pathological functions, including its interaction with mitochondrial membranes, ion channels, or apoptotic regulators. Such research may inform therapeutic strategies targeting TMEM141-associated pathways in disease contexts. Current challenges include validating its subcellular localization, resolving its 3D structure, and identifying binding partners—areas where recombinant protein-based assays are indispensable.

In summary, TMEM141 recombinant protein serves as a vital resource for decoding the enigmatic roles of this transmembrane protein in health and disease.

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