| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HOX1; ABD-B; HOX1G; HOX1.7 |
| Entrez GeneID | 3205 |
| clone | 1A12C1 |
| WB Predicted band size | 30.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human HOXA9 (AA: 1-272) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HOXA9抗体的3篇代表性文献及其摘要概述：
1. **文献名称**：*HOXA9 is a prognostic marker in acute myeloid leukemia*
**作者**：Golub TR 等
**摘要**：该研究通过Western blot和免疫组化(使用HOXA9特异性抗体)发现，HOXA9在急性髓系白血病(AML)中异常高表达，且其表达水平与患者生存率显著相关，提示HOXA9可作为AML的潜在预后标志物。
2. **文献名称**：*HOXA9 interacts with Meis1 to enhance proliferation in leukemia cells*
**作者**：Kroon E 等
**摘要**：研究利用HOXA9抗体进行染色质免疫沉淀(ChIP)和共免疫沉淀实验，揭示了HOXA9与转录因子Meis1的直接相互作用，并证实二者协同促进白血病细胞的增殖和自我更新能力。
3. **文献名称**：*HOXA9 antibody-based detection in solid tumors*
**作者**：Shah N 等
**摘要**：通过免疫组化分析乳腺癌组织样本(使用高特异性HOXA9单克隆抗体)，发现HOXA9在转移性肿瘤中显著上调，提示其在实体瘤进展中的潜在作用，为靶向治疗提供依据。
注：以上文献信息为示例性质，实际引用需核对具体论文来源及细节。
The HOXA9 antibody is a crucial tool for studying the HOXA9 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors that regulate embryonic development, cell differentiation, and tissue patterning. HOXA9. specifically, plays a pivotal role in hematopoiesis and leukemogenesis. Aberrant expression of HOXA9 is strongly linked to aggressive cancers, particularly acute myeloid leukemia (AML), where its overexpression correlates with poor prognosis. It also contributes to solid tumors, including breast and ovarian cancers, by promoting cell proliferation, inhibiting apoptosis, and enhancing metastatic potential.
HOXA9 antibodies enable researchers to detect and quantify HOXA9 protein levels in cells or tissues, using techniques like Western blotting, immunohistochemistry (IHC), or flow cytometry. These antibodies are essential for investigating HOXA9's functional roles, regulatory mechanisms, and interactions with other oncogenic pathways. Clinically, HOXA9 expression is being explored as a diagnostic or prognostic biomarker, and its targeting holds therapeutic potential. However, challenges remain in standardizing antibody specificity across different experimental conditions and sample types. Ongoing research aims to refine HOXA9 detection methods and elucidate its complex roles in both normal development and disease, driving advancements in precision oncology and biomarker discovery.
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