| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UTY |
| Uniprot No | O14607 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1347aa |
| 氨基酸序列 | MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCLTPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSS |
| 预测分子量 | 149,5 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于UTY重组蛋白的3篇代表性文献摘要概括(文献标题与作者为虚构示例，仅用于演示格式)：
1. **文献名称**: "UTY Encodes a Ubiquitous Y Chromosome–Specific Histone Demethylase with Functional Redundancy to UTX"
**作者**: Smith A, et al.
**摘要**: 研究通过重组UTY蛋白的体外实验，证明其具有组蛋白H3K27去甲基化酶活性，功能上与X染色体同源蛋白UTX部分冗余。重组UTY可部分挽救UTX缺陷细胞的表观遗传调控异常，提示其在胚胎发育中的补偿作用。
2. **文献名称**: "Recombinant UTY Protein Regulates MHC Class II Expression in Antigen-Presenting Cells"
**作者**: Zhang L, et al.
**摘要**: 利用重组UTY蛋白处理树突状细胞，发现其通过JAK-STAT信号通路抑制MHC II类分子表达，表明UTY可能通过调控免疫突触形成参与自身免疫疾病的性别差异机制。
3. **文献名称**: "Structural Characterization of UTY Recombinant Protein and Its Interaction with TLE3"
**作者**: Tanaka K, et al.
**摘要**: 通过X射线晶体学解析重组UTY蛋白的Jumonji结构域三维结构，揭示其与转录共抑制因子TLE3的特异性结合界面，为靶向UTY的男性特异性癌症治疗提供结构基础。
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**注意**：以上文献为示例性内容，实际研究中需通过PubMed或Web of Science以关键词"UTY recombinant protein"检索真实文献。UTY研究多聚焦于其在性别差异疾病、表观遗传及免疫逃逸中的功能，重组蛋白常被用于验证酶活性和蛋白互作。
**Background of UTY Recombinant Protein**
The UTY (Ubiquitously Transcribed Tetratricopeptide Repeat-Containing, Y-Linked) gene is located on the Y chromosome and encodes a protein belonging to the UTY/KDM6C family, which shares homology with the UTX/KDM6A protein. UTY functions as a histone demethylase, targeting trimethylated lysine 27 on histone H3 (H3K27me3), a modification linked to transcriptional repression. Unlike its X-linked homolog UTX, UTY retains partial enzymatic activity and plays roles in chromatin remodeling, gene regulation, and cellular differentiation.
UTY recombinant protein is engineered through molecular cloning, typically expressed in *E. coli* or mammalian systems, and purified for research applications. Its production enables the study of UTY-specific functions, particularly in contexts where Y chromosome genes are relevant, such as male-specific immunity or sex-biased diseases. Notably, UTY-derived peptides act as minor histocompatibility antigens (H-Y antigens), triggering immune responses in sex-mismatched transplants or autoimmune conditions. In cancer research, UTY is investigated for its role in modulating tumor microenvironments and immune evasion, especially in male-predominant cancers.
Additionally, UTY recombinant protein serves as a critical tool in autoimmune studies, as autoantibodies against UTY are observed in diseases like rheumatoid arthritis. Its use in structural and functional assays helps elucidate interactions with binding partners, such as chromatin modifiers or immune receptors. Despite challenges in studying Y chromosome genes due to their repetitive nature and sequence homology, recombinant UTY facilitates insights into sex-specific biological mechanisms and therapeutic targeting.
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