Mouse Monoclonal ESRRA Antibody

The Estrogen-Related Receptor Alpha (ESRRA), also known as ERRα, is a nuclear receptor transcription factor belonging to the NR3B subfamily. Unlike classical estrogen receptors, ESRRA does not bind estrogen but shares structural homology, regulating gene expression by binding to estrogen response elements (EREs) or ERR-specific response elements (ERREs). It plays a critical role in cellular energy homeostasis, mitochondrial biogenesis, oxidative metabolism, and adaptive responses to stress. ESRRA is highly expressed in tissues with elevated metabolic demands, such as the heart, brain, and skeletal muscle, and interacts with coactivators like PGC-1α to modulate metabolic pathways. Dysregulation of ESRRA has been implicated in cancer progression, metabolic disorders (e.g., diabetes, obesity), and neurodegenerative diseases. ESRRA antibodies are essential tools for detecting and quantifying ESRRA protein levels in techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies enable researchers to study ESRRA's expression patterns, post-translational modifications, and interactions in both physiological and pathological contexts. As ESRRA emerges as a potential therapeutic target, its antibodies also aid in drug development studies aimed at modulating ERRα activity to treat metabolic syndromes or cancer.