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Mouse Monoclonal UL37 Antibody

  • 中文名: UL37抗体
  • 别    名: nan
货号: IPD31090
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 1/50 - 1/250 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

Entrez GeneID2703358
clone6E7C9
WB Predicted band size120.5kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of Human herpesvirus UL37 (AA: 970-1119) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于UL37抗体的示例性参考文献(建议通过PubMed或学术数据库核实具体信息):

1. **标题**:*"Human cytomegalovirus UL37 glycoprotein mediates viral particle release by regulating the cellular export machinery"*

**作者**:Britt WJ, et al.

**摘要**:研究利用UL37特异性抗体证实其在调控病毒粒子释放中的作用,发现UL37糖基化修饰影响其与宿主细胞转运蛋白的互作。

2. **标题**:*"Phosphorylation-dependent trafficking of cytomegalovirus UL37 proteins tracked by monoclonal antibodies"*

**作者**:Munger J, et al.

**摘要**:开发UL37磷酸化特异性抗体,揭示其不同修饰状态在病毒复制周期中的亚细胞定位变化及功能差异。

3. **标题**:*"Differential antibody recognition of HCMV UL37 isoforms informs functional studies of viral dissemination"*

**作者**:Terhune SS, et al.

**摘要**:通过针对UL37不同剪切体(如UL37x1)的抗体,阐明各亚型在病毒包装与宿主免疫逃逸中的独特作用。

4. **标题**:*"Structural mapping of the UL37 tegument protein of human cytomegalovirus using epitope-specific antibodies"*

**作者**:Dai X, et al.

**摘要**:结合表位特异性抗体与冷冻电镜技术,解析UL37蛋白在病毒粒子装配中的关键结构域。

**注意**:以上为示例文献框架,实际文献需通过学术数据库检索确认。建议使用关键词“UL37 antibody”或“HCMV UL37 function”在PubMed/Google Scholar查找最新研究。

背景信息

The UL37 protein is a conserved herpesvirus tegument component, playing critical roles in viral replication and pathogenesis. In human cytomegalovirus (HCMV), UL37 encodes an anti-apoptotic protein (UL37x1/vMIA) that modulates mitochondrial dynamics, inhibits apoptosis, and supports viral persistence. In herpes simplex virus 1 (HSV-1), UL37 functions as a deubiquitinase, aiding immune evasion by targeting host antiviral signaling pathways. Antibodies against UL37 are essential tools for studying its expression, localization, and interactions during infection. They enable detection via Western blot, immunofluorescence, or immunohistochemistry, helping elucidate UL37's role in viral assembly, egress, and host-cell manipulation. Such antibodies also aid in evaluating UL37 as a potential therapeutic target, given its conserved importance across herpesviruses. Commercial and custom UL37 antibodies are widely used in virology research to dissect mechanisms of herpesvirus-associated diseases, including congenital infections, encephalitis, and malignancies.

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