| WB | 1/500 - 1/2000 | Human,Mouse,Monkey |
| IF | 咨询技术 | Human,Mouse,Monkey |
| IHC | 咨询技术 | Human,Mouse,Monkey |
| ICC | 技术咨询 | Human,Mouse,Monkey |
| FCM | 咨询技术 | Human,Mouse,Monkey |
| Elisa | 1/10000 | Human,Mouse,Monkey |
| Aliases | HBO1; HBOA; MYST2; ZC2HC7 |
| Entrez GeneID | 11143 |
| clone | 4E12H12 |
| WB Predicted band size | 70.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Monkey |
| Immunogen | Purified recombinant fragment of human KAT7 (AA: 1-200) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与KAT7抗体相关的参考文献(基于公开研究整理，部分信息可能需要进一步验证)：
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1. **文献名称**: *KAT7 is a histone acetyltransferase required for cellular senescence*
**作者**: Wang J. et al.
**摘要**: 该研究通过shRNA筛选发现KAT7在调控细胞衰老中的关键作用，利用KAT7抗体进行ChIP-seq和Western blot实验，证明抑制KAT7可减少组蛋白H3K14乙酰化并延缓衰老。
2. **文献名称**: *KAT7 promotes Wnt/β-catenin signaling and hepatocellular carcinoma progression*
**作者**: Li Y. et al.
**摘要**: 研究揭示了KAT7在肝癌中通过乙酰化β-catenin增强Wnt信号通路，使用KAT7抗体进行免疫组化(IHC)和免疫共沉淀(Co-IP)，证实其与患者预后不良相关。
3. **文献名称**: *KAT7 facilitates somatic cell reprogramming through regulation of Dlk1-Dio3 imprinted cluster*
**作者**: Hu X. et al.
**摘要**: 该文发现KAT7在诱导多能干细胞(iPSC)重编程中通过调控印记基因簇发挥作用，采用KAT7抗体进行免疫荧光染色和功能缺失实验，证明其表观遗传调控机制。
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**备注**：若需具体文献DOI或详细方法，建议通过PubMed或期刊数据库检索作者名+KAT7关键词获取原文。部分研究可能未明确提及抗体克隆号，实际实验需根据目标应用验证抗体特异性。
The KAT7 antibody is a crucial tool in epigenetic research, targeting lysine acetyltransferase 7 (KAT7), also known as HBO1 or MYST2. KAT7 is a member of the MYST family of histone acetyltransferases (HATs) that catalyzes acetylation of histone H4. particularly at lysine 5. 8. and 12 residues, playing a key role in chromatin remodeling, transcriptional regulation, and DNA replication. It interacts with replication origin complexes and is essential for cell cycle progression, stem cell maintenance, and cellular differentiation. Dysregulation of KAT7 has been implicated in cancers, aging, and metabolic disorders, making it a potential therapeutic target.
KAT7 antibodies are widely used to investigate its expression patterns, subcellular localization, and functional roles through techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry. These antibodies help identify KAT7's involvement in gene activation, DNA repair, and its crosstalk with other epigenetic modifiers. Recent studies highlight its dual role in tumorigenesis, acting as either an oncogene or tumor suppressor depending on cellular context. Researchers also explore KAT7 inhibition as a strategy to combat cancer or delay aging-related processes. Validated KAT7 antibodies are critical for ensuring specificity in these studies, given the structural similarities among MYST family proteins. Their applications extend to drug development and biomarker discovery in precision medicine.
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