| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200-1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DRRS; HSAL4; ZNF797; dJ1112F19.1 |
| Entrez GeneID | 57167 |
| clone | 1A3E11 |
| WB Predicted band size | 112kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Purified recombinant fragment of human SALL4 (954-1053) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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1. **"SALL4 is a novel diagnostic marker for germ cell tumors" by Cao et al.**
摘要：该研究验证了SALL4抗体在免疫组化中的应用，证明其在识别生殖细胞肿瘤(如精原细胞瘤和卵黄囊瘤)中的高敏感性和特异性，可作为病理诊断的关键标志物。
2. **"SALL4 expression in human stem cells and tissue development" by Yang et al.**
摘要：研究探讨了SALL4抗体在胚胎干细胞和多种成体组织中的表达模式，揭示了SALL4在维持干细胞多能性和早期发育调控中的关键作用。
3. **"Utility of SALL4 in the diagnosis of hepatocellular carcinomas" by Wang et al.**
摘要：通过分析肝癌样本，发现SALL4抗体在肝细胞癌中异常表达，尤其在低分化病例中显著，提示其作为肝癌诊断和预后评估的潜在生物标志物。
4. **"SALL4 immunohistochemistry in hematologic malignancies" by Li et al.**
摘要：研究评估了SALL4抗体在急性髓系白血病(AML)和骨髓增生异常综合征中的表达，表明SALL4阳性与特定亚型相关，可能指导临床分型和治疗策略。
(注：以上为虚拟文献示例，实际引用需通过PubMed等数据库检索真实论文。)
SALL4 antibody is a diagnostic and research tool targeting the SALL4 protein, a member of the Spalt-like (SALL) transcription factor family. SALL4. characterized by zinc finger domains, plays critical roles in embryonic development, particularly in maintaining pluripotency of stem cells and regulating organogenesis. It is highly expressed in embryonic stem cells, germ cells, and certain progenitor cells but is typically silenced in most adult tissues.
In pathology, SALL4 antibody is widely used as a biomarker for germ cell tumors (GCTs), including seminomas, yolk sac tumors, and embryonal carcinomas. Its nuclear staining pattern in immunohistochemistry (IHC) helps distinguish GCTs from other malignancies. Additionally, SALL4 is aberrantly expressed in some somatic cancers, such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and certain carcinomas, suggesting its oncogenic potential.
Research applications focus on SALL4's role in cancer progression, stem cell biology, and regenerative medicine. Studies indicate SALL4 promotes tumor cell proliferation, survival, and chemoresistance by regulating Wnt/β-catenin and other signaling pathways. However, its expression in healthy tissues is limited, making it a promising therapeutic target. The antibody also aids in exploring SALL4's involvement in developmental disorders like Okihiro syndrome, linked to SALL4 mutations. Commercially available monoclonal antibodies target specific isoforms (SALL4A/SALL4B), enabling precise functional studies. Overall, SALL4 antibody serves as a vital tool in both diagnostic pathology and molecular research.
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