Mouse Monoclonal C1QA Antibody

The C1q antibody targets the C1QA subunit, a critical component of the C1 complex in the complement system's classical pathway. C1q, a hexameric protein composed of three distinct chains (A, B, and C), acts as a pattern recognition molecule that initiates complement activation by binding to antigen-antibody complexes or pathogen surfaces. This interaction triggers a proteolytic cascade, ultimately leading to pathogen opsonization, inflammation, and cell lysis. C1QA antibodies are widely used in research to study complement-mediated immune responses, particularly in autoimmune diseases like systemic lupus erythematosus (SLE), where aberrant C1q binding to self-antigens drives tissue damage. They also aid in diagnosing complement deficiencies and analyzing C1q's role in neurodegenerative conditions, such as Alzheimer's disease, where complement dysregulation may contribute to pathology. Additionally, therapeutic strategies targeting C1q with monoclonal antibodies are being explored to mitigate complement-driven inflammation in autoimmune and inflammatory disorders. These antibodies enable precise detection of C1q localization in tissues, facilitating mechanistic studies of its dual roles in immune homeostasis and disease progression.