| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CNAP1; CAP-D2; hCAP-D2 |
| WB Predicted band size | 157 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NCAPD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NCAPD2抗体的3篇参考文献示例(注：文献为示例性质，具体内容可能需要根据实际研究调整)：
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1. **文献名称**: *NCAPD2 promotes hepatocellular carcinoma progression by regulating cell cycle and immune infiltration*
**作者**: Zhang Y, et al.
**摘要**: 研究利用NCAPD2抗体进行免疫组化和Western blot分析，发现NCAPD2在肝癌组织中高表达，并与细胞周期异常及患者不良预后相关。机制研究表明其通过调控CDK1通路促进肿瘤增殖。
2. **文献名称**: *NCAPD2 as a potential biomarker for colorectal cancer diagnosis and therapeutic targeting*
**作者**: Li X, et al.
**摘要**: 通过NCAPD2抗体检测结直肠癌组织样本，发现NCAPD2表达显著高于正常组织，且与肿瘤转移正相关。体外实验表明，抑制NCAPD2可降低癌细胞侵袭能力。
3. **文献名称**: *The role of NCAPD2 in mitotic chromosome condensation and genomic stability*
**作者**: Wang H, et al.
**摘要**: 利用NCAPD2抗体进行免疫荧光和ChIP-seq分析，揭示NCAPD2在维持有丝分裂染色体结构和基因组稳定性中的关键作用，其缺失导致染色体分离错误和细胞凋亡。
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如需获取真实文献，建议在PubMed或Google Scholar中以“NCAPD2 antibody”、“NCAPD2 biomarker”或“NCAPD2 cancer”为关键词检索。
The NCAPD2 antibody targets the Non-SMC Condensin II Complex Subunit D2 (NCAPD2), a key component of the condensin II complex involved in chromosome condensation and segregation during mitosis. NCAPD2 plays a critical role in maintaining genomic stability by ensuring proper chromatin organization and sister chromatid resolution. Dysregulation of NCAPD2 has been linked to chromosomal instability, aneuploidy, and carcinogenesis, making it a focus in cancer biology and genetic disorder research.
Antibodies against NCAPD2 are widely used in molecular and cellular studies to investigate its expression, localization, and interaction partners. They enable techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to explore NCAPD2's role in cell cycle regulation, DNA repair, and transcriptional control. These antibodies are particularly valuable in cancer research, where altered NCAPD2 expression has been observed in tumors such as glioblastoma, hepatocellular carcinoma, and breast cancer.
Commercial NCAPD2 antibodies are typically raised in hosts like rabbits or mice, with validation including knockout cell line controls to confirm specificity. Researchers also utilize these reagents to study developmental defects linked to condensin II dysfunction. Proper validation remains essential due to potential cross-reactivity with structurally similar condensin subunits.
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