Rabbit Polyclonal FBH1 Antibody

The FBH1 (F-box DNA helicase 1) antibody is a tool used to study the FBH1 protein, a multifunctional enzyme involved in DNA damage repair and replication stress responses. FBH1 belongs to the F-box protein family, characterized by a conserved F-box domain that facilitates interactions with SKP1-CUL1-F-box (SCF) ubiquitin ligase complexes. It also contains a helicase domain, enabling DNA unwinding activity. FBH1 plays dual roles in genome maintenance: it suppresses excessive homologous recombination (HR) by displacing RAD51 filaments from single-stranded DNA, while also promoting replication fork restart under stress. Dysregulation of FBH1 is linked to genomic instability and cancer progression. Researchers use FBH1 antibodies primarily in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression patterns, subcellular localization, and interactions with repair proteins (e.g., BRCA1. BLM). Recent studies focus on FBH1's potential as a therapeutic target, particularly in cancers with HR deficiencies, where FBH1 inhibition may synergize with PARP inhibitors or chemotherapy. The antibody's specificity and validation across experimental models remain critical for elucidating FBH1's context-dependent roles in DNA repair pathways and cellular survival mechanisms.