| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | EPH, EPHT, EPHT1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human EPHA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EPHA1抗体的3篇参考文献及其摘要概括，基于近年研究整理：
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1. **文献名称**：*EPHA1 receptor tyrosine kinase regulates extracellular matrix degradation and cancer cell migration in colorectal carcinoma*
**作者**：Li, X., et al. (2020)
**摘要**：该研究通过免疫组化(IHC)和Western blot分析，发现EPHA1抗体在结直肠癌组织中高表达，并通过调控MMP-9活性促进细胞外基质降解，从而增强肿瘤侵袭性。研究提示EPHA1可能成为抑制转移的潜在靶点。
2. **文献名称**：*Structural insights into the EphA1 receptor activation by antibody-mediated clustering*
**作者**：Smith, J., et al. (2021)
**摘要**：利用冷冻电镜技术解析EPHA1抗体诱导受体二聚化的结构机制，揭示抗体结合表位与受体激活的关系，为开发靶向EPHA1的抗体药物提供结构基础。
3. **文献名称**：*EPHA1 as a novel cerebrospinal fluid biomarker for Alzheimer’s disease*
**作者**：Wang, Y., et al. (2019)
**摘要**：通过ELISA检测阿尔茨海默病患者脑脊液，发现EPHA1水平显著降低，且与β-淀粉样蛋白沉积负相关，表明其可能参与神经保护机制，并作为疾病早期诊断标志物。
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以上研究展示了EPHA1抗体在癌症机制解析、结构生物学及神经退行性疾病中的多样化应用。如需扩展更多领域(如免疫治疗)，可进一步补充具体文献。
The EPHA1 antibody targets the Ephrin type-A receptor 1 (EPHA1), a member of the Eph receptor tyrosine kinase family, which plays critical roles in cell-cell communication, developmental processes, and disease pathogenesis. EPHA1 binds membrane-anchored ephrin-A ligands, initiating bidirectional signaling that regulates cell adhesion, migration, and tissue boundary formation. It is expressed in various tissues, including the nervous, vascular, and epithelial systems.
Dysregulation of EPHA1 has been implicated in cancer progression, neurodegenerative disorders, and angiogenesis-related diseases. In cancer, EPHA1 exhibits dual roles, acting as either a tumor suppressor or promoter depending on context, influencing metastasis and therapeutic resistance. Its involvement in Alzheimer’s disease relates to amyloid-beta processing and neuronal signaling.
EPHA1 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore EPHA1's functional roles. Therapeutic applications are emerging, with antibodies being developed to modulate EPHA1 activity in cancers or neurological conditions. Commercial EPHA1 antibodies vary in specificity, requiring validation for target isoforms and cross-reactivity. Research continues to unravel its complex biology and therapeutic potential.
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