Rabbit Polyclonal EPHA4 Antibody

The EPHA4 antibody targets the Ephrin type-A receptor 4 (EPHA4), a member of the Eph receptor tyrosine kinase family. EPHA4 plays critical roles in cell-cell communication, guiding cellular migration, adhesion, and tissue patterning during development. It interacts with membrane-bound ephrin ligands, triggering bidirectional signaling that regulates neuronal axon guidance, synaptic plasticity, and vascular development. Dysregulation of EPHA4 is implicated in diseases such as cancer, neurodegenerative disorders (e.g., ALS, Alzheimer's), and spinal cord injury. EPHA4 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are used in techniques like Western blot, immunohistochemistry, and immunofluorescence to visualize EPHA4 distribution in tissues or cells. Additionally, therapeutic applications are being explored, as inhibiting EPHA4 signaling with neutralizing antibodies or small molecules has shown promise in enhancing nerve regeneration and slowing disease progression in preclinical models. The antibody's specificity for EPHA4's extracellular or intracellular domains determines its utility in blocking ligand binding or downstream kinase activity, respectively, making it a versatile reagent in both basic research and drug development.