| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | FRA; FRA1; fra-1 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human FOSL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOSL1抗体的3篇参考文献示例(文献为虚构，仅作格式参考)：
1. **文献名称**: *FOSL1 promotes tumor invasion by regulating MMP-9 expression in colorectal cancer*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过Western blot和免疫组化(使用FOSL1抗体)证明，FOSL1通过上调MMP-9促进结直肠癌侵袭，且其表达与患者预后不良相关。
2. **文献名称**: *Validation of a novel FOSL1 monoclonal antibody for immunohistochemical analysis in triple-negative breast cancer*
**作者**: Lee S, et al.
**摘要**: 文章验证了一种特异性FOSL1单克隆抗体的可靠性，证实其在三阴性乳腺癌组织中可清晰标记FOSL1蛋白，并发现FOSL1高表达与化疗耐药性相关。
3. **文献名称**: *FOSL1 drives EMT and metastasis in lung adenocarcinoma through Slug activation*
**作者**: Wang H, et al.
**摘要**: 通过免疫荧光(使用FOSL1抗体)和基因敲除实验，揭示FOSL1通过激活Slug诱导上皮-间质转化(EMT)，从而促进肺腺癌转移。
4. **文献名称**: *Comparative analysis of FOSL1 antibody performance across species and cancer models*
**作者**: Gupta R, et al.
**摘要**: 比较多种FOSL1抗体的交叉反应性和特异性，确定某克隆号抗体在小鼠和人类组织中的一致性检测效果，为跨物种研究提供依据。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed。)
The FOSL1 antibody is a crucial tool for studying the FOS-like antigen 1 (FOSL1), a member of the FOS family of transcription factors. FOSL1. also known as Fra-1. forms the AP-1 transcription complex by dimerizing with JUN proteins, regulating genes involved in cell proliferation, differentiation, and apoptosis. It plays a significant role in development, tissue homeostasis, and pathological processes, including cancer. FOSL1 is often overexpressed in aggressive tumors (e.g., breast, lung, and colorectal cancers), where it promotes epithelial-mesenchymal transition (EMT), metastasis, and therapy resistance by modulating extracellular matrix remodeling and survival pathways.
FOSL1 antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to detect FOSL1 expression and localization in cells and tissues. These antibodies help researchers investigate FOSL1's regulatory mechanisms, such as its activation by oncogenic signaling pathways (e.g., MAPK/ERK) and post-translational modifications. Studies using FOSL1 antibodies have highlighted its dual role as both an oncogene and a tumor suppressor, depending on cellular context. Additionally, they aid in exploring FOSL1's involvement in inflammatory diseases and stromal interactions in the tumor microenvironment. Reliable FOSL1 antibodies are essential for understanding its contribution to disease progression and developing targeted therapies.
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