| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ALDR; ABC39; ALDL1; ALDRP; hALDR |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ABCD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCD2抗体的参考文献示例(注：以下内容为示例，实际引用时请核对文献真实性)：
1. **文献名称**: "The role of ABCD2 in X-linked adrenoleukodystrophy: functional complementation and regulatory mechanisms"
**作者**: Kemp S, Wanders RJA
**摘要**: 研究探讨了ABCD2蛋白在X-连锁肾上腺脑白质营养不良(ALD)中的作用，发现其与ABCD1具有部分功能重叠，可能通过过氧化物酶体脂肪酸转运缓解疾病表型。实验使用ABCD2抗体验证蛋白在细胞模型中的表达定位。
2. **文献名称**: "Transcriptional regulation of ABCD2 by PPARα in peroxisomal disorders"
**作者**: Fourcade S, et al.
**摘要**: 通过染色质免疫沉淀和抗体检测，揭示了过氧化物酶体增殖物激活受体α(PPARα)对ABCD2基因的调控机制，表明其在脂代谢疾病中可能作为治疗靶点。
3. **文献名称**: "ABCD2 antibody-based analysis of peroxisomal ABC transporters in murine models"
**作者**: Morita M, Fujiki Y
**摘要**: 研究利用ABCD2特异性抗体分析小鼠肝脏和脑组织中的蛋白表达，发现其在过氧化物酶体β-氧化中的代偿功能，尤其在ABCD1缺陷模型中表达上调。
4. **文献名称**: "Targeting ABCD2 in neurodegenerative diseases: antibody validation and therapeutic potential"
**作者**: Lopez-Erauskin J, et al.
**摘要**: 通过Western blot和免疫组化验证了ABCD2抗体的特异性，并证明在ALD患者细胞中增强ABCD2表达可减少毒性脂肪酸累积，提示其治疗潜力。
建议通过PubMed或Google Scholar检索上述作者近期研究，获取准确文献信息及全文链接。
The ABCD2 antibody targets the ATP-binding cassette subfamily D member 2 (ABCD2), a peroxisomal transmembrane protein involved in transporting very-long-chain fatty acids (VLCFAs) into peroxisomes for β-oxidation. ABCD2 shares structural and functional homology with ABCD1. whose mutations cause X-linked adrenoleukodystrophy (X-ALD), a severe neurodegenerative disorder. While ABCD1 deficiency leads to VLCFA accumulation, ABCD2 is thought to partially compensate for ABCD1 dysfunction, making it a focus in studying peroxisomal disorders and metabolic regulation.
ABCD2 is highly expressed in tissues with active lipid metabolism, such as the liver, brain, and adrenal glands. Research using ABCD2 antibodies has helped elucidate its role in cellular stress responses, neuroprotection, and lipid homeostasis. These antibodies are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess ABCD2 expression levels, subcellular localization, and interactions in disease models, including ABCD2-knockout mice or X-ALD cell lines.
Recent studies also explore ABCD2's potential as a therapeutic target, as its upregulation might mitigate metabolic imbalances in peroxisomal diseases. The antibody's specificity and validation in detecting endogenous ABCD2 remain critical for advancing mechanistic insights into peroxisome-related pathologies and metabolic syndrome.
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