| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | LIND; ABIN-3 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TNIP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TNIP3抗体的虚构参考文献示例(仅供示例参考，非真实文献)：
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1. **文献名称**：*TNIP3 modulates NF-κB signaling through interaction with ubiquitin chains*
**作者**：Lee S, et al.
**摘要**：研究通过TNIP3抗体进行免疫共沉淀和Western blot，发现TNIP3通过与泛素链结合抑制NF-κB通路活性，影响炎症反应调控。
2. **文献名称**：*TNIP3 antibody-based profiling reveals its tumor-suppressive role in hepatocellular carcinoma*
**作者**：Zhang Y, et al.
**摘要**：利用TNIP3特异性抗体进行免疫组化分析，证明TNIP3在肝癌组织中低表达，并通过调控细胞凋亡抑制肿瘤生长。
3. **文献名称**：*TNIP3 regulates viral innate immunity via interaction with RIG-I*
**作者**：Kumar A, et al.
**摘要**：通过TNIP3抗体的免疫荧光染色，发现TNIP3与RIG-I蛋白互作，负向调控抗病毒天然免疫信号通路。
4. **文献名称**：*TNIP3 deficiency exacerbates autoimmune disorders in murine models*
**作者**：Müller R, et al.
**摘要**：采用TNIP3敲除小鼠及抗体检测，揭示TNIP3缺失导致B细胞过度活化，促进系统性红斑狼疮等自身免疫疾病发展。
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**注意**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实文献。
TNIP3 (TNFAIP3-interacting protein 3), also known as ABIN3. is a ubiquitin-binding protein that regulates inflammatory signaling pathways, particularly those mediated by NF-κB. It shares structural homology with other ABIN family members (TNIP1. TNIP2) and contains conserved domains, including a ubiquitin-binding domain (UBAN) and an NF-κB essential modulator (NEMO)-binding domain. TNIP3 interacts with TNFAIP3 (A20), a critical negative regulator of NF-κB, to modulate immune responses, apoptosis, and cell survival. Dysregulation of TNIP3 has been implicated in autoimmune diseases, cancers, and inflammatory disorders.
Antibodies targeting TNIP3 are essential tools for investigating its expression, localization, and molecular interactions. They enable researchers to study TNIP3's role in fine-tuning NF-κB activation, either by stabilizing A20's deubiquitinase activity or through competitive binding with other signaling components. Western blotting, immunohistochemistry, and co-immunoprecipitation are common applications. Studies using TNIP3 antibodies have revealed tissue-specific expression patterns and disease-associated alterations, such as reduced levels in lupus or aberrant expression in certain lymphomas. However, challenges remain in distinguishing TNIP3 from homologous proteins due to sequence conservation, necessitating rigorous antibody validation. These reagents continue to advance our understanding of TNIP3's dual roles as a tumor suppressor and context-dependent oncogenic collaborator.
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