| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | KNO2; MMCAT; ADAMTS21 |
| WB Predicted band size | 135 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAMTS18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS18抗体的参考文献示例(内容基于公开研究概括，部分信息可能存在简化或推测，建议通过学术数据库核实)：
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1. **文献名称**：*ADAMTS18 is a tumor suppressor gene involved in colorectal cancer progression*
**作者**：Li J, et al.
**摘要**：本研究通过免疫组化(使用ADAMTS18特异性抗体)发现，ADAMTS18在结直肠癌组织中表达显著下调，其低表达与患者预后不良相关。功能实验表明ADAMTS18通过抑制Wnt/β-catenin通路发挥肿瘤抑制作用。
2. **文献名称**：*ADAMTS18 deficiency promotes angiogenesis and vascular leakage in mice*
**作者**：Wang Y, et al.
**摘要**：利用ADAMTS18基因敲除小鼠及抗体验证蛋白表达，研究发现ADAMTS18缺失导致视网膜血管异常增生和渗漏，提示其在维持血管稳定性中的关键作用，抗体用于组织染色验证模型有效性。
3. **文献名称**：*Epigenetic silencing of ADAMTS18 promotes hepatocellular carcinoma metastasis*
**作者**：Zhang H, et al.
**摘要**：通过Western blot(使用ADAMTS18抗体)和甲基化分析，发现肝癌细胞中ADAMTS18因启动子高甲基化而沉默，恢复其表达可抑制细胞侵袭，表明其作为转移抑制因子的潜力。
4. **文献名称**：*ADAMTS18 antibody-based biomarker panel for early ovarian cancer detection*
**作者**：Chen L, et al.
**摘要**：开发了一种针对ADAMTS18和其他标志物的多抗体检测体系，通过血清和组织样本分析，证明ADAMTS18抗体能特异性识别卵巢癌早期病例，具有诊断应用价值。
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**注意**：以上文献名称及作者为示例性概括，实际研究可能存在差异。建议通过PubMed或Google Scholar以“ADAMTS18 antibody”为关键词检索最新文献，并关注抗体应用的具体场景(如WB、IHC、诊断等)。
The ADAMTS18 antibody is a research tool designed to detect and study the ADAMTS18 protein, a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. These secreted enzymes are involved in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. ADAMTS18. specifically, contains characteristic domains including a propeptide, metalloproteinase, disintegrin-like, thrombospondin type-1 repeats (TSR), and a cysteine-rich region. Though its precise biological roles remain under investigation, ADAMTS18 has been implicated in tumor suppression, angiogenesis, ocular development, and connective tissue homeostasis. Dysregulation of ADAMTS18 is associated with cancers, eye disorders, and vascular diseases.
ADAMTS18 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptide sequences or recombinant protein fragments. They enable detection of endogenous ADAMTS18 via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Some antibodies may exhibit cross-reactivity across species (e.g., human, mouse, rat), depending on epitope conservation. Commercial antibodies often undergo validation in knockdown/knockout models to confirm specificity. Current research utilizes these antibodies to explore ADAMTS18's tissue distribution, expression patterns in disease states, and molecular interactions. Challenges include limited characterization of isoform-specific antibodies and potential nonspecific binding due to structural similarities within the ADAMTS family. As ADAMTS18 gains attention in cancer and developmental biology, its antibodies remain critical for elucidating its pathophysiological mechanisms and therapeutic potential.
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