| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ADAMTS19 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS19抗体的模拟参考文献示例(注：部分文献为示例性概括，实际研究可能需要进一步检索验证)：
1. **"ADAMTS19在心血管发育中的功能及其抗体应用"**
*作者：Smith A, et al.*
摘要：本研究通过制备ADAMTS19特异性抗体，揭示了该蛋白在小鼠心脏瓣膜发育中的关键作用。抗体用于免疫组化分析，显示ADAMTS19缺失导致细胞外基质异常重塑。
2. **"ADAMTS19抗体在骨关节炎模型中的治疗潜力"**
*作者：Wang X, et al.*
摘要：利用单克隆ADAMTS19抗体抑制其蛋白酶活性，发现可减缓软骨退变，提示ADAMTS19可能成为骨关节炎治疗的靶点。抗体特异性通过Western blot验证。
3. **"ADAMTS19在肿瘤侵袭中的机制研究"**
*作者：Chen L, et al.*
摘要：通过ADAMTS19中和抗体阻断其功能，证实该蛋白通过调控TGF-β通路促进乳腺癌细胞迁移。抗体应用于体外迁移实验及小鼠模型。
4. **"人源ADAMTS19多克隆抗体的制备与验证"**
*作者：Kim H, et al.*
摘要：研究报道了针对人ADAMTS19抗原表位的多克隆抗体的开发流程，验证了其在免疫沉淀和免疫荧光中的应用，为后续功能研究提供工具。
**注意**：ADAMTS19的研究相对较少，上述文献为示例性概括，实际检索建议通过PubMed或Google Scholar结合关键词(如"ADAMTS19 antibody")获取最新进展。
The ADAMTS19 antibody is designed to target the ADAMTS19 protein, a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. This family comprises secreted zinc-dependent proteases involved in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. ADAMTS19. encoded by the ADAMTS19 gene on human chromosome 5. shares structural features with other family members, including a propeptide, catalytic domain, disintegrin-like module, thrombospondin type 1 (TSP1) repeats, and a C-terminal ancillary domain. Its precise biological functions remain less characterized compared to other ADAMTS proteases (e.g., ADAMTS13 in von Willebrand factor cleavage). However, emerging studies suggest roles in connective tissue homeostasis, skeletal development, and reproductive system regulation. Dysregulation of ADAMTS19 has been tentatively linked to pathologies such as osteoarthritis, cardiovascular diseases, and cancer progression, though mechanistic insights are limited.
ADAMTS19 antibodies are primarily used as research tools to detect protein expression, localization, and activity in tissues or cell lines. Polyclonal or monoclonal antibodies are generated against specific epitopes (e.g., catalytic or TSP1 domains) and validated via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). Their applications include studying ADAMTS19's involvement in ECM dynamics, signaling pathways, and disease models. Commercial availability varies, with some antibodies optimized for human, mouse, or rat homologs. Challenges include ensuring specificity due to structural similarities among ADAMTS family members. Recent interest in ADAMTS19 as a potential therapeutic target or biomarker underscores the need for well-validated antibodies to advance functional and clinical research.
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