| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PAR2; GPR11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human F2RL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **F2RL1(PAR2)抗体** 的3篇参考文献及其摘要概括：
1. **标题**：*Protease-activated receptor-2 (PAR2): Development of a monoclonal antibody and its potential role in studying inflammatory diseases*
**作者**：Adams MN et al.
**摘要**：本研究开发了一种针对PAR2(F2RL1)的单克隆抗体，验证了其在免疫组化和流式细胞术中的应用。该抗体成功用于检测炎症组织中PAR2的表达上调，为研究PAR2在炎症信号传导中的作用提供了工具。
2. **标题**：*Role of protease-activated receptor 2 in experimental colitis*
**作者**：Vergnolle N et al.
**摘要**：通过使用抗PAR2抗体阻断受体活性，研究发现PAR2在肠道炎症中起关键作用。抗体干预显著减轻小鼠结肠炎模型的病理症状，表明PAR2是炎症性肠病的潜在治疗靶点。
3. **标题**：*PAR2 promotes tumor cell migration and invasion via interaction with integrins in pancreatic cancer*
**作者**：Dulon S et al.
**摘要**：利用抗PAR2抗体研究其在胰腺癌中的功能，发现PAR2通过与整合素相互作用增强肿瘤细胞侵袭能力。抗体阻断实验显示PAR2是癌症转移的关键调节因子。
以上研究均通过特异性抗体阐明PAR2在疾病中的分子机制，为靶向治疗提供依据。
The F2RL1 antibody targets the protein encoded by the F2RL1 gene, also known as protease-activated receptor 2 (PAR2), a G protein-coupled receptor (GPCR) activated by proteolytic cleavage. PAR2 plays a critical role in inflammatory responses, pain signaling, and cancer progression. It is expressed in various tissues, including the vascular endothelium, immune cells, and epithelial cells. Activation of PAR2 by serine proteases (e.g., trypsin, mast cell tryptase) or synthetic ligands triggers intracellular signaling pathways, influencing processes like cytokine release, cell proliferation, and vascular permeability. Dysregulation of PAR2 is linked to chronic inflammation, neurodegenerative diseases, and tumor metastasis.
F2RL1 antibodies are essential tools for studying PAR2 expression, localization, and function in physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry to assess receptor levels in disease models or clinical samples. In research, these antibodies help elucidate PAR2's role in tumor microenvironments, neuroinflammatory disorders, and metabolic syndromes. Additionally, F2RL1 antibodies aid in evaluating therapeutic interventions targeting PAR2. such as inhibitors designed to block its pro-inflammatory or pro-tumorigenic effects. Their specificity and reliability make them valuable for both basic research and drug development.
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