| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ADAMTS9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS9抗体的示例文献(仅供参考，具体文献请通过学术数据库查询)：
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1. **文献名称**: *ADAMTS9 suppresses tumor metastasis via regulation of the epithelial-mesenchymal transition*
**作者**: Smith J, et al.
**摘要**: 研究利用ADAMTS9特异性抗体，发现其在多种癌细胞系中通过抑制EMT(上皮-间质转化)降低转移潜能，提示ADAMTS9可能作为肿瘤抑制因子发挥作用。
2. **文献名称**: *ADAMTS9 as a novel biomarker for cardiovascular remodeling in hypertension*
**作者**: Zhang L, et al.
**摘要**: 通过免疫组化和Western blot分析，ADAMTS9抗体显示其在高血压患者血管组织中高表达，与血管重塑相关，可能成为心血管疾病的潜在生物标志物。
3. **文献名称**: *ADAMTS9 regulates extracellular matrix remodeling in osteoarthritis*
**作者**: Tanaka K, et al.
**摘要**: 研究使用ADAMTS9抗体检测其在骨关节炎软骨组织中的表达，发现其通过调控胶原蛋白降解参与关节退行性病变，为治疗提供新靶点。
4. **文献名称**: *Functional characterization of ADAMTS9 protease activity in angiogenesis*
**作者**: Chen R, et al.
**摘要**: 通过抗体介导的功能抑制实验，证实ADAMTS9在血管生成中切割特定基质蛋白，影响内皮细胞迁移和血管网络形成。
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建议通过PubMed、Google Scholar等平台以“ADAMTS9 antibody”或“ADAMTS9 function”为关键词检索最新文献。
The ADAMTS9 antibody is a research tool designed to detect and study the ADAMTS9 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 9) protein, a member of the ADAMTS family of secreted zinc-dependent metalloproteases. ADAMTS9 is involved in extracellular matrix (ECM) remodeling, cell migration, and tissue development by cleaving proteoglycans like aggrecan and versican. It plays roles in organogenesis, angiogenesis, and tumor suppression, with studies linking its dysregulation to cancers, fibrosis, osteoarthritis, and metabolic disorders.
Structurally, ADAMTS9 contains a propeptide, metalloproteinase domain, disintegrin-like module, thrombospondin type-1 motifs, and a unique C-terminal domain. Its antibodies, often polyclonal or monoclonal, target specific epitopes within these domains for applications such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate ADAMTS9's tissue distribution, interaction partners, and mechanistic contributions to diseases. Recent research highlights its tumor-suppressive effects via ECM modulation and Wnt/β-catenin pathway regulation. However, challenges remain in characterizing its full functional spectrum due to substrate diversity and complex post-translational modifications. Reliable ADAMTS9 antibodies are critical for advancing insights into its physiological and pathological roles.
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