| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NKG2C; CD159c; NKG2-C |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KLRC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLRC2抗体的模拟参考文献示例(注：内容为虚构，仅作格式参考)：
1. **标题**：NKG2C (KLRC2) Antibody Characterization in Cytomegalovirus Infection
**作者**：Smith A, et al.
**摘要**：研究通过流式细胞术验证KLRC2抗体的特异性，发现其在CMV感染者中可有效标记NKG2C+ NK细胞，揭示NKG2C与病毒免疫应答的关联。
2. **标题**：KLRC2-Specific Antibodies in Tumor-Infiltrating Lymphocyte Analysis
**作者**：Lee B, et al.
**摘要**：利用KLRC2抗体分析肿瘤微环境中NK细胞亚群，发现NKG2C高表达与患者生存率改善相关，提示其作为免疫治疗生物标志物的潜力。
3. **标题**：Genetic Variation of KLRC2 and Antibody-Based Phenotyping
**作者**：Garcia C, et al.
**摘要**：结合基因测序与KLRC2抗体检测，证实KLRC2基因多态性影响NK细胞表面NKG2C蛋白表达水平，为个体化免疫研究提供依据。
4. **标题**：Role of KLRC2 in HIV Progression: Antibody-Driven Functional Assays
**作者**：Johnson R, et al.
**摘要**：通过KLRC2抗体阻断实验，发现NKG2C+ NK细胞在HIV感染中具有抑制病毒复制的作用，提示靶向KLRC2的潜在治疗策略。
(注：以上文献信息为模拟生成，实际引用需查询真实数据库如PubMed。)
The KLRC2 antibody targets the protein encoded by the *KLRC2* gene, also known as NKG2C (Natural Killer Group 2. member C). This protein is a type II transmembrane receptor predominantly expressed on natural killer (NK) cells and certain cytotoxic T lymphocytes. It forms heterodimers with CD94. creating the CD94/NKG2C receptor complex, which recognizes HLA-E molecules on target cells. HLA-E typically presents peptides derived from other HLA class I molecules, enabling NK cells to monitor cellular health. Activation of the CD94/NKG2C receptor generally transmits inhibitory or activating signals depending on associated adaptor proteins, though NKG2C is primarily linked to activating functions through its interaction with DAP12.
KLRC2 antibodies are essential tools for studying NK cell biology, particularly in viral infections (e.g., cytomegalovirus) and cancer immunology, where NKG2C+ NK cells exhibit adaptive-like features. These antibodies are used in flow cytometry, immunohistochemistry, and functional assays to characterize NK cell subsets, receptor expression dynamics, and cytotoxic responses. Dysregulation of KLRC2 expression has been implicated in autoimmune disorders, chronic infections, and transplant outcomes, making its antibody valuable for both research and clinical diagnostics. Commercial KLRC2 antibodies are typically validated for specificity against recombinant or endogenous proteins, with applications spanning basic immunology to therapeutic development.
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