| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P311; PTZ17; SEZ17; D4S114; C5orf13; PRO1873 |
| WB Predicted band size | 8 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human NREP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为3篇与NREP(Neuronal Regeneration-Related Protein)抗体相关的示例参考文献(注：部分内容为示例性概括，实际文献需通过学术数据库验证)：
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1. **文献名称**: "NREP promotes axonal regeneration through interactions with the mTOR pathway"
**作者**: Smith J, et al.
**摘要**: 本研究利用特异性NREP抗体进行Western blot和免疫组化分析，发现NREP在周围神经损伤后显著上调，并通过激活mTOR信号通路促进轴突再生。抗体特异性验证显示其对NREP蛋白的高亲和力。
2. **文献名称**: "Expression profiling of NREP in human cancers: A potential biomarker for metastasis"
**作者**: Johnson L, et al.
**摘要**: 通过免疫组织化学(使用兔源抗NREP单克隆抗体)分析多种癌症组织样本，发现NREP在转移性乳腺癌中高表达，且与患者预后不良相关，提示其作为癌症生物标志物的潜力。
3. **文献名称**: "NREP interacts with cytoskeletal proteins to regulate neuronal migration"
**作者**: Lee S, et al.
**摘要**: 研究采用NREP抗体进行免疫共沉淀和免疫荧光实验，证实NREP与β-actin和Tubulin存在相互作用，调控发育中神经元的迁移过程，为神经发育障碍提供机制解释。
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**提示**：以上文献为示例，实际研究中建议通过PubMed、Web of Science等平台以"NREP antibody"或"Neuronal regeneration protein antibody"为关键词检索最新文献，并关注抗体应用场景(如物种特异性、实验方法等)。
NREP (Neuron-Derived Regeneration-Related Protein), also known as MRLP or C4orf7. is a conserved protein encoded by the *NREP* gene in humans. Initially identified for its role in neuronal regeneration, it has since been linked to broader cellular processes, including tissue repair, cell migration, and cancer progression. Structurally, NREP contains an EF-hand calcium-binding domain and a PDZ-binding motif, suggesting involvement in calcium signaling and protein-protein interactions.
NREP is ubiquitously expressed, with higher levels in the brain, heart, and skeletal muscles. It regulates pathways like TGF-β, MAPK, and Wnt, influencing epithelial-mesenchymal transition (EMT) and extracellular matrix remodeling. In neural contexts, NREP promotes axonal growth and synaptic plasticity, potentially aiding recovery after injury. Conversely, its upregulation in cancers (e.g., breast, colorectal, gastric) correlates with enhanced metastasis, chemoresistance, and poor prognosis, likely via EMT activation and stromal interaction.
Antibodies targeting NREP are critical tools for studying its expression, localization, and function. They enable detection in immunoassays (Western blot, IHC) and functional studies (knockdown/overexpression experiments). Recent research explores NREP as a therapeutic target, with antibodies potentially blocking its pro-metastatic effects or enhancing regenerative pathways. However, its dual roles in regeneration and cancer necessitate context-specific investigation. Ongoing studies aim to clarify NREP's mechanistic nuances and therapeutic potential across diseases.
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