| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HACL1; HACL-1; KAP11.1 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KRTAP11-1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRTAP11-1抗体的3篇模拟参考文献示例(注：文献为虚构，仅用于示例)：
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1. **文献名称**: *Immunolocalization and Functional Analysis of KRTAP11-1 in Human Hair Keratinization*
**作者**: Lee S, et al.
**摘要**: 本研究利用兔源多克隆抗体，通过免疫组化和Western blot揭示了KRTAP11-1在人类毛囊角质化区域的特异性表达，证实其参与调控毛发硬度的分子机制。
2. **文献名称**: *KRTAP11-1 as a Potential Biomarker in Cutaneous Squamous Cell Carcinoma: Antibody Development and Clinical Validation*
**作者**: Gupta M, et al.
**摘要**: 开发了小鼠单克隆抗KRTAP11-1抗体，用于检测皮肤鳞癌组织中该蛋白的异常高表达，提示其可作为早期诊断或预后的生物标志物。
3. **文献名称**: *CRISPR/Cas9-Mediated KRTAP11-1 Knockout and Rescue Experiments Using Specific Antibodies for Protein Tracking*
**作者**: Wang Y, et al.
**摘要**: 结合CRISPR基因编辑技术及KRTAP11-1抗体，验证了该蛋白在表皮细胞分化中的必要性，并发现其缺失导致角质层结构缺陷。
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**说明**：以上文献为示例性质，实际研究中建议通过PubMed、Web of Science等平台检索真实发表的论文。若需具体文献，可补充基因的别名(如KAP11-1)或相关功能关键词扩大检索范围。
The KRTAP11-1 (Keratin-Associated Protein 11-1) gene encodes a member of the keratin-associated protein (KAP) family, which plays a structural role in hair and nail formation by interacting with keratin intermediate filaments. These proteins contribute to the mechanical strength and flexibility of hair through disulfide bond cross-linking. KRTAP11-1 is part of the high sulfur KAP group, localized on chromosome 21q22.1. and its expression is primarily restricted to the hair follicle cortex.
Antibodies targeting KRTAP11-1 are tools used to investigate its expression, localization, and function in hair biology and related disorders. They are typically produced in immunized hosts (e.g., rabbits or mice) using synthetic peptides or recombinant proteins as antigens. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding studies on hair shaft abnormalities, genetic variations (e.g., polymorphisms linked to hair traits), and diseases like monilethrix or hypotrichosis.
While research on KRTAP11-1 remains limited compared to other KAPs, its antibodies contribute to understanding hair keratinization mechanisms and potential therapeutic targets for hair disorders. Commercial availability varies, with some suppliers offering polyclonal or monoclonal options for experimental use. Validation data, including specificity and cross-reactivity, are critical for reliable application in research contexts.
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