| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX4; HOX4D; HOX4E; Hox-4.4 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXD10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与HOXD10抗体相关的文献摘要示例(注：内容为模拟概括，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *HOXD10 suppresses colorectal cancer metastasis via targeting integrin αvβ3/FAK signaling*
**作者**: Li Y, et al.
**摘要**: 研究利用HOXD10特异性抗体进行免疫组化和Western blot分析，发现HOXD10在结直肠癌组织中表达降低，其通过抑制整合素αvβ3/FAK通路抑制肿瘤侵袭转移。
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2. **文献名称**: *HOXD10 as a tumor suppressor in breast cancer through regulation of EMT*
**作者**: Garcia M, et al.
**摘要**: 通过HOXD10抗体染色显示，HOXD10在乳腺癌中高表达可抑制上皮-间质转化(EMT)，降低细胞迁移能力，提示其作为抑癌基因的潜在机制。
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3. **文献名称**: *Developmental regulation of HOXD10 in spinal cord patterning*
**作者**: Smith J, et al.
**摘要**: 研究利用HOXD10抗体进行小鼠胚胎神经组织免疫荧光染色，揭示HOXD10在脊髓背侧神经元分化中的时空表达模式及其对神经轴突导向的影响。
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4. **文献名称**: *HOXD10 antibody validation for functional studies in endometrial cancer*
**作者**: Wang H, et al.
**摘要**: 文献详细验证了HOXD10抗体的特异性(如siRNA敲降对照实验)，并应用于子宫内膜癌细胞系，证明HOXD10通过调控MMP-9抑制侵袭能力。
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如需具体文献，建议通过PubMed或Google Scholar以“HOXD10 antibody”或“HOXD10 function”为关键词检索近年研究。
The HOXD10 antibody is a tool used in biomedical research to detect the HOXD10 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors containing a conserved DNA-binding homeodomain, critical for regulating embryonic development, cell differentiation, and tissue patterning. Specifically, HOXD10. located on chromosome 2q31-32. plays roles in limb development, neural tube closure, and organogenesis. Dysregulation of HOXD10 has been implicated in cancer, where it may act as a tumor suppressor or promoter depending on context. For example, reduced HOXD10 expression is linked to metastasis in breast, colorectal, and cervical cancers, while its overexpression correlates with progression in gliomas and hepatocellular carcinoma.
The HOXD10 antibody enables researchers to study its expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available antibodies are typically raised against specific epitopes of the human HOXD10 protein, with validation in relevant cell lines or tissues. Understanding HOXD10's dual roles in development and disease highlights its potential as a diagnostic marker or therapeutic target, driving ongoing interest in reliable detection tools like this antibody. Proper controls, such as knockout validation, are essential to ensure specificity in experimental settings.
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