| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GAR22 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GAS2L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于GAS2L1抗体的3篇参考文献示例(注：以下文献为虚构示例，实际文献需通过学术数据库检索确认)：
---
1. **标题**: "GAS2L1 modulates cytoskeletal dynamics during cytokinesis through antibody-based localization studies"
**作者**: Bennin, D.A., et al.
**摘要**: 本研究利用特异性GAS2L1抗体，揭示其在哺乳动物细胞胞质分裂中的关键作用。通过免疫荧光实验发现，GAS2L1通过与微管和肌动蛋白结合，调控收缩环的稳定性。
---
2. **标题**: "GAS2L1 as a potential biomarker in colorectal cancer: Immunohistochemical analysis using a novel monoclonal antibody"
**作者**: Zhang, Y., et al.
**摘要**: 开发了一种高特异性抗GAS2L1单克隆抗体，用于结直肠癌组织分析。结果显示，GAS2L1表达水平与肿瘤侵袭性和患者预后显著相关，提示其作为诊断标志物的潜力。
---
3. **标题**: "The role of GAS2L1 in microtubule stabilization and its interaction with tau protein revealed by co-immunoprecipitation"
**作者**: Li, X., et al.
**摘要**: 通过GAS2L1抗体进行免疫共沉淀实验，发现GAS2L1通过稳定微管网络影响神经元形态，并与tau蛋白存在功能关联，为神经退行性疾病机制研究提供新方向。
---
如需真实文献，建议在 **PubMed** 或 **Google Scholar** 检索关键词：
`GAS2L1 antibody`、`GAS2L1 function`、`GAS2L1 biomarker`。
The GAS2L1 (Growth Arrest-Specific 2 Like 1) antibody is a tool used to study the GAS2L1 protein, a member of the GAS2 family involved in regulating cytoskeletal dynamics and cell cycle progression. GAS2L1 contains conserved domains (CH, GAR) that enable interactions with microtubules and microfilaments, playing a role in mitotic spindle organization and chromosome segregation during cell division. Research highlights its importance in maintaining genomic stability, with dysregulation linked to mitotic errors and cancer progression, such as glioblastoma and hepatocellular carcinoma.
This antibody is widely employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect GAS2L1 expression, localization, and interactions. Studies using the antibody have revealed its cell cycle-dependent expression, peaking during mitosis, and its role in cellular stress responses, including DNA damage repair. Notably, GAS2L1 knockdown experiments (supported by antibody validation) demonstrate its necessity for proper spindle assembly and chromosome alignment. Recent work also implicates GAS2L1 in neurodevelopmental processes and ciliogenesis. As an emerging biomarker and therapeutic target, the GAS2L1 antibody remains critical for unraveling its dual roles in physiological homeostasis and disease mechanisms.
×
