| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT119; VSIG3; Igsf13; BT-IgSF; CXADRL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IGSF11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及IGSF11抗体的文献摘要示例(文献为虚构，仅供格式参考)：
1. **《IGSF11 promotes hepatocellular carcinoma progression by activating STAT3 signaling》**
- 作者：Li X, et al.
- 摘要：本研究使用抗IGSF11抗体进行免疫组化分析，发现IGSF11在肝癌组织中高表达，并通过激活STAT3通路促进肿瘤侵袭和转移。
2. **《IGSF11 as a novel immune checkpoint molecule in T cell exhaustion》**
- 作者：Wang Y, et al.
- 摘要：通过流式细胞术和Western blot(使用特异性IGSF11抗体)证实，IGSF11在耗竭性T细胞表面高表达，抑制其功能，提示其可能成为免疫治疗的潜在靶点。
3. **《Structural characterization of IGSF11 extracellular domain using monoclonal antibodies》**
- 作者：Smith J, et al.
- 摘要：开发了针对IGSF11胞外域的单克隆抗体，通过冷冻电镜和结合实验解析了IGSF11的蛋白构象，揭示了其介导细胞间相互作用的分子机制。
4. **《IGSF11 mediates chemoresistance in colorectal cancer via integrin signaling》**
- 作者：Chen H, et al.
- 摘要：利用IGSF11抗体阻断实验证明，IGSF11通过整合素-FAK信号通路增强结直肠癌细胞对化疗药物的耐药性，提示靶向IGSF11可能改善治疗效果。
注：以上文献为示例性内容，实际研究中请通过PubMed或Google Scholar检索真实文献。
The immunoglobulin superfamily member 11 (IGSF11) is a transmembrane protein primarily involved in cell-cell adhesion and immune regulation. It shares structural homology with other immunoglobulin-like proteins, featuring extracellular immunoglobulin (Ig) domains that mediate homophilic or heterophilic interactions. IGSF11 is expressed in various tissues, including the immune system, brain, and epithelial cells, and plays roles in neuronal development, immune synapse formation, and epithelial barrier maintenance. Its dysregulation has been implicated in autoimmune disorders, neurodevelopmental conditions, and cancer metastasis.
Antibodies targeting IGSF11 are valuable tools for studying its expression, localization, and functional mechanisms. They enable applications like immunohistochemistry, flow cytometry, and Western blotting to map tissue distribution or quantify protein levels. In research, IGSF11 antibodies have helped uncover its role in T-cell activation, tumor immune evasion, and cell migration pathways. Some studies suggest IGSF11 may interact with checkpoint molecules like PD-1. positioning it as a potential therapeutic target in cancer immunotherapy. However, its precise signaling pathways and disease associations remain under investigation, necessitating further validation of antibody specificity and functional studies. Commercial IGSF11 antibodies are typically raised against extracellular domains to facilitate detection in live cells or intact tissues.
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