Rabbit Polyclonal IRF5 Antibody

The IRF5 (Interferon Regulatory Factor 5) antibody is a research tool used to detect and study the IRF5 protein, a transcription factor central to innate immune responses. IRF5 belongs to the IRF family, which regulates interferon (IFN) production and immune activation. It is activated downstream of Toll-like receptors (TLRs) and inflammasome pathways, driving the expression of proinflammatory cytokines (e.g., TNF-α, IL-6) and type I IFNs. Dysregulation of IRF5 has been implicated in autoimmune diseases like systemic lupus erythematosus (SLE), rheumatoid arthritis, and multiple sclerosis, as well as in certain cancers. IRF5 antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to analyze IRF5 expression, subcellular localization (e.g., nuclear translocation upon activation), and post-translational modifications. These studies help elucidate IRF5's role in disease pathogenesis, immune cell differentiation, and signaling crosstalk. Commercial IRF5 antibodies are typically validated for specificity in human, mouse, or rat samples, with applications in both basic research and therapeutic target validation. Recent studies also explore IRF5's dual roles in promoting inflammation or apoptosis in cancer contexts, making its antibody a critical reagent in immunology and oncology research.