| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IRAK; pelle |
| WB Predicted band size | 77 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human IRAK1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IRAK1抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*IRAK1 is a novel DEK target involved in inflammation and chemoresistance in acute myeloid leukemia*
**作者**：Li Y, et al.
**摘要**：研究利用IRAK1抗体通过Western blot和免疫沉淀技术，发现IRAK1在急性髓系白血病(AML)中高表达，并通过调控炎症信号通路促进化疗耐药，提示其作为治疗靶点的潜力。
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2. **文献名称**：*IRAK1-dependent signaling drives resistance to BTK inhibition in chronic lymphocytic leukemia*
**作者**：Wang X, et al.
**摘要**：通过免疫组化(IHC)和流式细胞术结合IRAK1抗体，揭示IRAK1在慢性淋巴细胞白血病(CLL)中通过激活NF-κB信号介导对BTK抑制剂的耐药性，提出联合抑制IRAK1可增强疗效。
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3. **文献名称**：*Targeting IRAK1 in T cells to ameliorate autoimmune disease*
**作者**：Svensson MN, et al.
**摘要**：研究使用IRAK1敲除小鼠及特异性抗体，证实IRAK1在T细胞中调控IL-17和IFN-γ的产生，抑制IRAK1可减轻类风湿性关节炎等自身免疫疾病的炎症反应。
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如需具体文献年份或期刊信息，可进一步补充关键词检索。
Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine kinase that plays a critical role in innate immune signaling pathways, particularly those activated by Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). Upon ligand binding, IRAK1 is recruited to receptor complexes via adaptor proteins like MyD88. leading to its phosphorylation and activation. This triggers downstream signaling cascades, including NF-κB and MAPK pathways, which drive inflammatory cytokine production and immune responses. Dysregulation of IRAK1 has been linked to autoimmune diseases, chronic inflammation, and cancers, making it a target for therapeutic research.
IRAK1 antibodies are essential tools for studying its expression, post-translational modifications, and interactions in immune signaling. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate IRAK1's role in health and disease. Specific antibodies can distinguish between phosphorylated (active) and unphosphorylated forms, aiding in the analysis of signaling dynamics. Additionally, IRAK1-targeting antibodies have therapeutic potential, with some studies exploring their use in blocking aberrant signaling in inflammatory disorders. As research advances, these antibodies remain crucial for unraveling IRAK1's complex functions and developing precision therapies.
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