Rabbit Polyclonal KIF14 Antibody

The KIF14 antibody is a tool used to detect KIF14. a kinesin motor protein involved in mitosis and cytokinesis. KIF14. encoded by the *KIF14* gene, plays a critical role in regulating microtubule dynamics during cell division, particularly in the transport of vesicles and organelles. Structurally, it contains an N-terminal motor domain for ATP-dependent microtubule binding and a C-terminal cargo-binding domain. Dysregulation of KIF14 is linked to cancer progression, as overexpression is observed in neuroblastoma, breast, lung, and ovarian cancers, often correlating with poor prognosis. The KIF14 antibody enables researchers to study its expression, localization, and interaction partners (e.g., PRC1. a cytokinesis regulator) in cellular models or tumor tissues. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore KIF14's role in tumorigenesis, therapy resistance, or as a potential biomarker. Recent studies also investigate its therapeutic targeting, as inhibiting KIF14 disrupts cancer cell proliferation. However, its non-mitotic functions in neuronal development or tissue homeostasis remain less understood, highlighting the need for further research using validated KIF14-specific antibodies.