| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C16orf44 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KLHL36 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KLHL36抗体的模拟参考文献示例(请注意，以下内容为假设性示例，实际文献可能需要通过学术数据库检索获取)：
1. **文献名称**：*KLHL36 Antibody Development and Its Role in Protein Ubiquitination*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种高特异性KLHL36多克隆抗体，验证了其在Western blot和免疫组化中的应用。研究发现KLHL36作为E3泛素连接酶复合体的组分，参与调控细胞周期相关蛋白的泛素化降解。
2. **文献名称**：*KLHL36 Expression Profiling in Gastrointestinal Cancers Using a Novel Monoclonal Antibody*
**作者**：Chen L, et al.
**摘要**：通过新型单克隆抗体检测KLHL36在结直肠癌和胃癌组织中的表达，发现其表达水平与肿瘤分化程度呈负相关，提示KLHL36可能作为潜在的癌症生物标志物。
3. **文献名称**：*Functional Characterization of KLHL36 in Neuronal Development via Antibody-Mediated Knockdown*
**作者**：Garcia R, et al.
**摘要**：利用KLHL36抗体进行功能阻断实验，证明其在神经元突触形成中的作用。研究表明KLHL36通过调控突触蛋白稳定性影响神经发育。
4. **文献名称**：*KLHL36 Antibody Cross-Reactivity Analysis Across Species*
**作者**：Tanaka K, et al.
**摘要**：评估了KLHL36抗体在小鼠、大鼠和人类样本中的交叉反应性，为跨物种比较研究提供实验依据，并揭示了KLHL36在进化中的保守性特征。
**建议**：如需真实文献，可通过PubMed或Google Scholar检索关键词“KLHL36 antibody”，并筛选涉及抗体开发、验证或功能研究的论文。部分研究可能聚焦于KLHL36的分子机制，而非直接描述抗体，需结合摘要内容判断相关性。
The KLHL36 antibody is a tool used to detect the KLHL36 protein, a member of the Kelch-like (KLHL) family characterized by conserved BTB (Bric-a-brac, Tramtrack, Broad Complex), BACK (BTB and C-terminal Kelch), and Kelch repeat domains. These domains enable KLHL36 to interact with substrates and participate in the assembly of Cullin-RING ubiquitin ligase (CRL) complexes, which regulate protein ubiquitination and degradation. While the precise biological roles of KLHL36 remain under investigation, KLHL proteins are broadly implicated in cellular processes such as oxidative stress response, cytoskeletal organization, and cell cycle regulation. KLHL36 is hypothesized to act as a substrate adaptor, targeting specific proteins for proteasomal degradation, though its exact substrates and physiological functions are not yet fully characterized.
Antibodies against KLHL36 are essential for studying its expression patterns, subcellular localization, and interaction networks. They are employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore KLHL36's tissue distribution, potential involvement in diseases, or regulatory mechanisms. Dysregulation of KLHL family proteins has been linked to cancers, neurodegenerative disorders, and metabolic syndromes, positioning KLHL36 as a potential biomarker or therapeutic target. However, research on KLHL36 is still in early stages, and its antibody serves as a critical reagent for unraveling its biological significance. Further studies are needed to clarify its role in cellular pathways and disease contexts.
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