| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C1orf172 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KDF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KDF1抗体的3篇模拟参考文献(注：KDF1相关研究较少，以下内容为示例性虚构，建议通过PubMed或Google Scholar检索真实文献)：
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1. **文献名称**：*KDF1 Antibody Characterization and Its Role in Epithelial Differentiation*
**作者**：Chen L, et al.
**摘要**：本研究开发了一种针对KDF1蛋白的高特异性多克隆抗体，验证了其在免疫印迹和免疫荧光中的有效性。实验表明，KDF1在皮肤角质形成细胞分化过程中表达上调，并通过调控Wnt信号通路影响细胞分化进程。
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2. **文献名称**：*KDF1 as a Novel Biomarker in Ovarian Cancer: Insights from Antibody-Based Detection*
**作者**：Wang Y, et al.
**摘要**：通过抗KDF1单克隆抗体的应用，研究发现KDF1在卵巢癌组织中异常高表达，且与患者预后不良相关。抗体阻断实验表明，抑制KDF1可降低肿瘤细胞的侵袭能力，提示其作为治疗靶点的潜力。
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3. **文献名称**：*Structural Insights into KDF1 Protein-Antibody Interactions via Cryo-EM*
**作者**：Smith J, et al.
**摘要**：利用冷冻电镜技术解析了KDF1蛋白与其单克隆抗体的复合物结构，揭示了抗体结合表位位于KDF1的C端结构域。该研究为开发基于KDF1抗体的诊断工具提供了分子基础。
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**提示**：实际研究中关于KDF1抗体的文献较少，建议结合具体研究方向(如发育生物学、癌症研究等)扩大检索范围，或联系抗体生产商(如Abcam、Sigma-Aldrich)获取技术文档。
The KDF1 (Keratinocyte Differentiation Factor 1) antibody is a tool used to study the KDF1 protein, which plays a critical role in epithelial cell differentiation and tissue development. KDF1. also known as C14orf28 or FOJ1. is a transcription factor implicated in regulating keratinocyte maturation and skin barrier formation. It is primarily expressed in stratified squamous epithelia, including the epidermis, oral mucosa, and esophagus. Research suggests KDF1 interacts with signaling pathways like Notch and Wnt, influencing cell fate decisions during development and homeostasis.
Antibodies targeting KDF1 enable researchers to investigate its expression patterns, subcellular localization, and functional mechanisms in both normal and pathological contexts. These antibodies are commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of KDF1 has been linked to skin disorders, cancer progression (particularly squamous cell carcinoma), and congenital ectodermal defects. Recent studies highlight its potential as a biomarker or therapeutic target in dermatological and oncological research.
The development of KDF1 antibodies has advanced understanding of epithelial biology, offering insights into tissue repair, carcinogenesis, and genetic diseases affecting ectodermal derivatives. Commercial antibodies are typically validated for specificity using knockout cell lines or tissues to ensure reliable experimental outcomes. Ongoing research continues to explore KDF1's broader roles in development and disease.
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