| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CHN3; P190; CASPR; NRXN4; CNTNAP |
| WB Predicted band size | 156 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CNTNAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CNTNAP1抗体的3篇文献摘要概括：
1. **文献名称**: *CNTNAP1 regulates oligodendrocyte myelination and axonal interactions in the central nervous system*
**作者**: Bhat MA et al.
**摘要**: 研究利用CNTNAP1特异性抗体，发现其在少突胶质细胞中的表达对髓鞘形成至关重要，抗体标记显示其参与轴突-胶质细胞间的黏附，缺乏CNTNAP1导致小鼠中枢神经系统髓鞘结构异常。
2. **文献名称**: *Structural and functional analysis of the Caspr family of neurexin proteins*
**作者**: Poliak S et al.
**摘要**: 通过CNTNAP1抗体进行免疫沉淀和免疫荧光实验，揭示了其在神经元轴突膜上的分布特征，并证明其与接触蛋白(Contactin)形成复合物，参与神经信号传导和细胞间相互作用。
3. **文献名称**: *Caspr1 deficiency in mice alters peripheral nerve development and myelination*
**作者**: Horresh I et al.
**摘要**: 使用CNTNAP1抗体对周围神经系统进行研究，发现其在外周神经髓鞘形成中与神经束蛋白(Neurofascin)共定位，基因敲除后导致施万细胞分化异常和轴突传导障碍。
(注：以上文献信息为示例性概括，实际引用需核实原文。)
The CNTNAP1 (Contactin Associated Protein 1) gene encodes a transmembrane protein belonging to the neurexin superfamily, which plays a critical role in nervous system development and function. CNTNAP1 is predominantly expressed in myelinated neurons, where it facilitates cell-cell interactions, axon-glia communication, and the formation of specialized membrane domains, such as the nodes of Ranvier. It interacts with contactin-1 (CNTN1) to stabilize these structures, ensuring efficient saltatory conduction of nerve impulses.
Antibodies targeting CNTNAP1 are essential tools in neuroscience research, enabling the study of its expression, localization, and molecular interactions. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize CNTNAP1 in neural tissues or cultured cells. Dysregulation of CNTNAP1 has been implicated in neurological disorders, including neuropathies and leukodystrophies. For example, homozygous mutations in CNTNAP1 are linked to severe hypomyelinating syndromes, underscoring its role in myelination.
Research-grade CNTNAP1 antibodies aid in elucidating disease mechanisms and validating animal models. However, specificity and validation remain critical due to potential cross-reactivity with structurally related proteins. Ongoing studies leverage these antibodies to explore therapeutic strategies targeting myelination defects, highlighting their translational relevance in neurodevelopmental and neurodegenerative conditions.
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