| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DRG11; PRRXL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DRGX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于DRGX抗体的假设性参考文献示例(注：DRGX可能为虚构或特定领域缩写，以下内容为模拟文献信息)：
---
1. **文献名称**: "DRGX Antibody Characterization in Nociceptive Neurons"
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对DRGX蛋白(背根神经节特异性钙通道调控因子)的高特异性抗体。通过免疫组化与Western blot分析，证实该抗体能特异性识别小鼠和人类DRG组织中的DRGX蛋白，并揭示了其在慢性疼痛模型中的表达上调。
2. **文献名称**: "Role of DRGX in Neuropathic Pain: Insights from Antibody-Based Inhibition"
**作者**: Chen L, et al.
**摘要**: 利用DRGX中和抗体，研究团队发现阻断DRGX可显著缓解大鼠神经病理性疼痛行为。抗体通过抑制DRGX与TRPV1通道的相互作用，减少外周敏化，为疼痛治疗提供了新靶点。
3. **文献名称**: "DRGX Antibody Cross-Reactivity Analysis Across Species"
**作者**: Tanaka K, et al.
**摘要**: 该文献系统评估了商业化DRGX抗体在啮齿类、灵长类动物中的交叉反应性，发现部分抗体存在非特异性结合问题，强调了抗体验证在神经科学研究中的重要性，并推荐了优化方案。
4. **文献名称**: "Developmental Expression of DRGX Protein Using Novel Monoclonal Antibodies"
**作者**: Patel R, et al.
**摘要**: 研究团队制备了针对DRGX的单克隆抗体，通过胚胎及成年小鼠DRG分析，揭示了DRGX在感觉神经元成熟过程中的动态表达模式，提示其可能参与痛觉通路的发育调控。
---
**备注**：以上文献为示例性内容，实际研究中请通过学术数据库(如PubMed、Web of Science)以“DRGX antibody”及相关关键词检索最新文献。若DRGX为特定研究领域术语，建议结合上下文进一步核实缩写定义。
The DRGX antibody targets the Dorsal Root Ganglion Homeobox Protein (DRGX), also known as PRRXL1. a transcription factor critical in sensory neuron development. Discovered for its specific expression in dorsal root ganglia (DRG), DRGX plays a role in regulating the differentiation and functional maturation of nociceptive neurons, which are essential for pain perception. It belongs to the PRRX family of homeobox proteins, which are involved in embryonic patterning and tissue-specific gene regulation. Research has shown that DRGX is selectively expressed in small-diameter DRG neurons, particularly those associated with nociception and thermosensation, making it a biomarker for studying pain pathways.
The DRGX antibody has become a valuable tool in neuroscience research, enabling the identification and characterization of DRGX-expressing neurons in both developmental and pathological contexts. Studies using this antibody have explored its involvement in neuropathic pain, inflammatory pain, and nerve injury models, shedding light on molecular mechanisms underlying chronic pain conditions. Additionally, DRGX's regulatory role in axon guidance and synaptic connectivity has been investigated, linking it to sensory circuit assembly.
As a research reagent, the DRGX antibody is widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize spatial and temporal expression patterns. Its application continues to advance understanding of sensory biology and potential therapeutic targets for pain management.
×
