Rabbit Polyclonal HTRA4 Antibody

The HTRA4 antibody is a tool used to detect and study the HTRA4 protein, a member of the high-temperature requirement A (HtrA) serine protease family. HTRA4. encoded by the *HTRA4* gene, is involved in proteolytic processes that regulate extracellular matrix (ECM) remodeling, cell signaling, and apoptosis. It plays critical roles in placental development, vascular homeostasis, and tissue repair. Research has linked HTRA4 dysregulation to pregnancy-related disorders like pre-eclampsia, where elevated HTRA4 levels in maternal blood correlate with impaired trophoblast invasion and placental dysfunction. In cancer biology, HTRA4 is studied for its dual roles—acting as a tumor suppressor in some contexts by promoting apoptosis or as a pro-metastatic factor in others by facilitating ECM degradation. The HTRA4 antibody is essential in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to quantify protein expression, localize it within tissues, or investigate its interaction with substrates. Recent studies also explore HTRA4 as a potential biomarker for disease prognosis or a therapeutic target. Structurally, HTRA4 contains a catalytic serine protease domain and a PDZ domain, which mediates protein-protein interactions. Its activity is tightly regulated by stress conditions, pH, and substrate binding, making it a dynamic player in cellular responses to environmental changes.