| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HB2A; KAP1.1; KAP1.6; KAP1.7; KAP1.1A; KAP1.1B; KRTAP1A; hKAP1.7; KRTAP1.1 |
| WB Predicted band size | 18 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KRTAP1-1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KRTAP1-1抗体的示例参考文献(部分为假设性描述，实际文献需通过学术数据库验证)：
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1. **文献名称**：*Development of a Monoclonal Antibody Specific for Human KRTAP1-1 and Its Application in Hair Follicle Analysis*
**作者**：Smith J, et al.
**摘要**：本研究成功开发了一种针对人类KRTAP1-1蛋白的单克隆抗体，并通过免疫组化证实其在毛囊中的特异性表达，为研究毛发结构异常提供了工具。
2. **文献名称**：*Altered Expression of KRTAP1-1 in Androgenetic Alopecia: Insights from Immunoblotting Studies*
**作者**：Lee S, et al.
**摘要**：利用KRTAP1-1抗体进行蛋白质印迹分析，发现雄激素性脱发患者的毛囊中KRTAP1-1表达显著下调，提示其可能在毛发生长调控中起重要作用。
3. **文献名称**：*Characterization of KRTAP1-1 Interaction with Keratin Fibers Using Co-Immunoprecipitation*
**作者**：Zhang R, et al.
**摘要**：通过KRTAP1-1抗体进行免疫共沉淀实验，揭示了该蛋白与角蛋白纤维的相互作用机制，支持其在毛发强度维持中的功能。
4. **文献名称**：*Validation of a Polyclonal Anti-KRTAP1-1 Antibody for Cross-Species Reactivity*
**作者**：Johnson M, et al.
**摘要**：评估了一种多克隆抗体在人类、小鼠等多物种中的交叉反应性，证实其在毛囊发育模型研究中的适用性。
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**注意**：上述文献为示例，实际研究可能需通过PubMed、Google Scholar等平台检索关键词“KRTAP1-1 antibody”或“Keratin-Associated Protein 1-1”获取。若需具体文献，建议结合最新数据库查询。
The KRTAP1-1 antibody targets keratin-associated protein 1-1 (KRTAP1-1), a member of the keratin-associated protein (KAP) family. These proteins are critical components of hair and nails, interacting with keratin intermediate filaments to form the structural matrix of hair shafts. KRTAP1-1. encoded by the *KRTAP1-1* gene on human chromosome 17q21.2. is a cysteine-rich protein believed to contribute to hair strength and elasticity through disulfide crosslinking. Its expression is predominantly localized to the hair follicle's cortical and cuticle layers during the anagen (growth) phase.
Antibodies against KRTAP1-1 are primarily used in biomedical research to investigate hair biology and disorders. They enable detection of KRTAP1-1 in tissue samples via immunohistochemistry (IHC) or Western blotting, aiding studies on hair follicle development, cycling, and diseases like alopecia or structural hair abnormalities. Some studies suggest KRTAP1-1 polymorphisms may influence hair texture or susceptibility to damage, making these antibodies valuable for genetic association analyses.
Commercial KRTAP1-1 antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant proteins. Validation includes specificity testing in keratinocyte cultures or hair follicle tissues. Challenges include potential cross-reactivity with other KAP family members due to sequence homology. Ongoing research focuses on clarifying KRTAP1-1's precise role in hair disorders and exploring diagnostic or therapeutic applications.
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