| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RMP; gep; NNX3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GNA12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GNA12抗体的3篇参考文献示例(文献信息为模拟概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**: *"GNA12 promotes tumor invasion and angiogenesis in breast cancer through activation of the STAT3 pathway"*
**作者**: Smith A, et al.
**摘要**: 本研究利用GNA12特异性抗体进行免疫沉淀和Western blot分析，发现GNA12通过激活STAT3信号通路增强乳腺癌细胞的侵袭和血管生成能力，提示其作为治疗靶点的潜力。
2. **文献名称**: *"Development of a monoclonal antibody targeting GNA12 for functional studies in hepatocellular carcinoma"*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种新型抗GNA12单克隆抗体的开发，并通过免疫组化验证其在肝细胞癌组织中的高表达，证明该抗体可用于检测GNA12的亚细胞定位及临床预后评估。
3. **文献名称**: *"GNA12-mediated signaling regulates ovarian cancer cell migration via RhoA activation"*
**作者**: Tanaka K, et al.
**摘要**: 研究使用GNA12抗体进行基因沉默和信号通路分析，发现GNA12通过调控RhoA GTPase活性促进卵巢癌细胞迁移，为靶向G蛋白偶联受体通路提供理论依据。
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如需具体文献，建议在PubMed或Web of Science中检索关键词“GNA12 antibody”或结合研究场景筛选。
**Background of GNA12 Antibody**
GNA12 (Guanine Nucleotide-Binding Protein Subunit Alpha-12) is a member of the Gα12/13 subfamily of heterotrimeric G-protein α-subunits, which transduce signals from G protein-coupled receptors (GPCRs) to regulate diverse cellular processes, including cytoskeletal remodeling, cell migration, and proliferation. GNA12 interacts with Rho GTPase-activating proteins (RhoGAPs) and guanine nucleotide exchange factors (RhoGEFs) to modulate RhoA/ROCK signaling pathways, influencing cell adhesion, motility, and oncogenic transformation. Dysregulation of GNA12 is implicated in cancer progression, cardiovascular disorders, and neurological diseases.
Antibodies targeting GNA12 are critical tools for studying its expression, localization, and functional roles. They are commonly used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate GNA12-mediated signaling in physiological and pathological contexts. Specific GNA12 antibodies are validated for species reactivity (e.g., human, mouse, rat) and application-specific compatibility. Researchers rely on these antibodies to explore GNA12's contribution to tumor invasiveness, metastasis, and therapeutic resistance, as well as its interactions with downstream effectors. High-quality GNA12 antibodies ensure specificity, often verified via knockout controls, supporting their utility in both basic research and translational studies aimed at targeting GNA12-related pathways for disease intervention.
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