Rabbit Polyclonal COX8A Antibody

The COX8A antibody targets the cytochrome c oxidase subunit 8A (COX8A), a nuclear-encoded component of mitochondrial Complex IV in the electron transport chain. This subunit plays a critical role in oxidative phosphorylation by facilitating the transfer of electrons from cytochrome c to molecular oxygen, a process essential for ATP synthesis. COX8A exists in two isoforms (COX8A and COX8B) with tissue-specific expression; COX8A is predominantly expressed in liver, pancreas, and kidney, while COX8B is found in heart and skeletal muscle. Antibodies against COX8A are widely used to study mitochondrial function, metabolic disorders, and diseases linked to oxidative phosphorylation defects, such as cancer and neurodegenerative conditions. They are valuable tools for applications like Western blotting, immunofluorescence, and immunohistochemistry to assess COX8A expression levels, subcellular localization, or mitochondrial integrity. Researchers also employ COX8A antibodies to investigate tissue-specific energy metabolism, cellular stress responses, or mitochondrial dynamics in disease models. Specificity is a key consideration, as cross-reactivity with COX8B or other COX subunits may occur depending on epitope design. These antibodies are frequently utilized in studies exploring metabolic reprogramming in cancer, aging-related mitochondrial dysfunction, or drug-induced mitochondrial toxicity.