| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SMCC; Sm-Calp; HEL-S-14 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CNN1抗体的3篇参考文献的简要整理(注：文献标题和作者为虚构示例，仅供说明格式)：
1. **文献名称**: "CNN1 Expression in Vascular Smooth Muscle Cells: Role in Atherosclerosis"
**作者**: Zhang L, et al.
**摘要**: 本研究利用CNN1抗体通过免疫组化和Western blot分析，发现动脉粥样硬化模型中CNN1表达下调，提示其可能通过调节平滑肌细胞收缩参与疾病进展。
2. **文献名称**: "CNN1 as a Biomarker in Gastrointestinal Stromal Tumors"
**作者**: Kim S, et al.
**摘要**: 通过CNN1抗体的免疫组织化学染色，研究者发现CNN1在胃肠道间质瘤中高表达，并与肿瘤侵袭性相关，可能作为预后标志物。
3. **文献名称**: "CNN1 in Fibroblast-to-Myofibroblast Transition"
**作者**: Müller R, et al.
**摘要**: 研究使用CNN1抗体检测肺纤维化模型中的肌成纤维细胞转化，证实CNN1表达升高与TGF-β信号通路激活相关，为抗纤维化治疗提供靶点。
**备注**：实际文献需通过PubMed/Google Scholar等平台检索关键词“CNN1 antibody”“Calponin 1 application”获取。建议结合具体研究场景筛选近年高引论文。
CNN1 antibody targets calponin-1. a 34-kDa actin-binding protein belonging to the calponin family. Primarily expressed in smooth muscle cells, calponin-1 regulates contractile activity by modulating actin-myosin interactions. It contains conserved CH domains, actin-binding sites, and calmodulin-binding regions, enabling its role in cytoskeletal organization and mechanotransduction. CNN1 is implicated in smooth muscle differentiation, cell migration, and vascular remodeling, with altered expression linked to cardiovascular diseases, atherosclerosis, and cancer metastasis.
As a research tool, CNN1 antibody is widely used in Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study smooth muscle cell phenotypes in tissues or cultured models. It helps identify pathological changes in vascular disorders, gastrointestinal motility diseases, and tumor microenvironments. Studies also explore its downregulation in certain cancers (e.g., prostate, breast) as a potential biomarker for epithelial-mesenchymal transition (EMT) or metastatic progression.
Commercial CNN1 antibodies are typically raised against peptide sequences specific to human or murine calponin-1. validated for cross-reactivity across species. Researchers should verify antibody specificity using knockout controls due to homology with calponin-2/3 isoforms. Its applications extend to developmental biology, fibrosis research, and drug screening targeting smooth muscle dysfunction.
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