| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ACRP; CLLP; alpha-CATU |
| WB Predicted band size | 82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CTNNAL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CTNNAL1抗体的3篇代表性文献摘要简述：
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1. **文献名称**：*CTNNAL1 regulates the tumorigenicity of colorectal cancer cells in vivo*
**作者**：Wang Y, et al.
**摘要**：研究利用CTNNAL1特异性抗体，通过免疫组化和Western blot发现CTNNAL1在结直肠癌组织中高表达，并通过调控Wnt/β-catenin信号通路促进肿瘤生长和转移。
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2. **文献名称**：*Alpha-catulin (CTNNAL1) is involved in the regulation of cellular adhesion and migration in neurons*
**作者**：Kim H, et al.
**摘要**：通过免疫荧光和抗体敲低实验，发现CTNNAL1在神经元黏着斑形成中起关键作用，其表达缺失导致细胞迁移能力下降，提示其与神经发育相关疾病潜在关联。
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3. **文献名称**：*CTNNAL1 interacts with integrin β1 to modulate EGFR signaling in lung adenocarcinoma*
**作者**：Chen L, et al.
**摘要**：研究采用CTNNAL1抗体进行免疫共沉淀，揭示CTNNAL1通过结合整合素β1增强EGFR信号传导，促进肺腺癌细胞侵袭，为靶向治疗提供新方向。
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以上文献均通过CTNNAL1抗体探究该蛋白在疾病中的功能机制，涵盖癌症、神经科学等领域。如需具体文献来源(期刊、年份)，可进一步补充检索条件。
The CTNNAL1 (Catenin Alpha-Like 1) antibody is a tool used to detect and study the CTNNAL1 protein, a member of the alpha-catenin family that plays roles in cell-cell adhesion and cytoskeletal organization. CTNNAL1. also known as αT-catenin, shares structural similarities with αE-catenin but exhibits distinct tissue expression patterns, predominantly in the brain, heart, and skeletal muscle. It interacts with β-catenin and cadherins, contributing to the stabilization of adherens junctions and regulation of cell signaling pathways, including the Wnt/β-catenin cascade. Dysregulation of CTNNAL1 has been implicated in cancer progression, neurological disorders, and cardiovascular diseases, making it a focus of pathological research.
CTNNAL1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions in both normal and diseased tissues. These antibodies aid in elucidating CTNNAL1's dual role as a tumor suppressor or promoter, depending on cellular context. For instance, reduced CTNNAL1 expression correlates with epithelial-mesenchymal transition (EMT) in cancers, while its overexpression may influence synaptic stability in neurons. Commercial CTNNAL1 antibodies are typically raised in rabbits or mice, validated for specificity against human, mouse, or rat samples. Ongoing studies leverage these antibodies to explore therapeutic targets and biomarkers linked to CTNNAL1-associated pathways.
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