| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | CKLFSF2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CMTM2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CMTM2抗体的研究文献示例(内容基于模拟生成，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *CMTM2 suppresses tumor growth and enhances anti-tumor immunity via inhibiting the PI3K/AKT pathway in melanoma*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用CMTM2特异性抗体，通过免疫组化和Western blot技术，发现CMTM2在黑色素瘤组织中表达显著下调。实验证实CMTM2通过抑制PI3K/AKT通路抑制肿瘤生长，并增强CD8+ T细胞浸润，提示其作为免疫治疗靶点的潜力。
2. **文献名称**: *CMTM2 is essential for sperm maturation and male fertility in mice*
**作者**: Li H, et al.
**摘要**: 通过免疫荧光和流式细胞术结合抗CMTM2抗体，研究发现CMTM2在小鼠精子形成阶段高表达，敲除CMTM2导致精子形态异常及雄性不育，揭示了其在生殖系统中的关键作用。
3. **文献名称**: *Development and validation of a novel monoclonal antibody against human CMTM2 for diagnostic applications*
**作者**: Chen X, et al.
**摘要**: 本研究开发了一种高特异性抗人CMTM2单克隆抗体，经ELISA、免疫印迹及免疫组织化学验证，证实其在多种癌组织中的检测敏感性和可靠性，为CMTM2相关病理研究提供了工具。
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**建议**：可通过PubMed或Google Scholar搜索关键词“CMTM2 antibody”、“CMTM2 function”获取最新文献，部分研究可能涉及抗体应用机制或疾病关联。
CMTM2 (CKLF-like MARVEL transmembrane domain-containing protein 2) is a member of the CMTM family, which shares structural features with both chemokines and MARVEL domain-containing proteins. It is widely expressed in human tissues, particularly in immune and reproductive systems, and plays roles in cell signaling, proliferation, and migration. Studies suggest CMTM2 is involved in immune regulation, tumorigenesis, and male reproductive system development. For example, it is highly expressed in the testes and may regulate spermatogenesis. In cancer, CMTM2 has been proposed as a tumor suppressor, with reduced expression linked to progression in malignancies like prostate and gastric cancers.
CMTM2 antibodies are essential tools for detecting and characterizing the protein’s expression, localization, and function. They are used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study CMTM2’s role in physiological and pathological contexts. Research utilizing these antibodies has highlighted CMTM2’s involvement in modulating EGFR and Wnt/β-catenin signaling pathways, potentially influencing cancer cell behavior. Additionally, CMTM2 antibodies aid in exploring its interaction with other immune-related molecules, contributing to understanding immune evasion mechanisms in tumors. These reagents are critical for both basic research and clinical investigations aiming to clarify CMTM2’s diagnostic or therapeutic potential.
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