| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MKP6; MKP-L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DUSP14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP14抗体的3篇参考文献示例(注：文献信息为模拟生成，仅供参考，实际引用需通过学术数据库核实)：
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1. **标题**: "DUSP14 regulates T-cell activation via modulation of JNK signaling"
**作者**: Zhang Y, et al.
**摘要**: 研究报道DUSP14通过负调控JNK磷酸化抑制T细胞过度活化，使用DUSP14抗体验证其在T细胞中的蛋白表达，并发现其缺失导致自身免疫反应增强。
2. **标题**: "DUSP14 suppresses LPS-induced inflammation by dephosphorylating p38 MAPK"
**作者**: Li H, Wang X.
**摘要**: 通过DUSP14抗体检测巨噬细胞中蛋白表达水平，发现DUSP14通过去磷酸化p38 MAPK减轻脂多糖(LPS)诱导的炎症反应，提示其作为潜在抗炎靶点。
3. **标题**: "Dual role of DUSP14 in hepatocellular carcinoma progression"
**作者**: Chen J, et al.
**摘要**: 利用DUSP14抗体进行免疫组化分析，发现DUSP14在肝癌中表达异常，既能抑制肿瘤生长(通过ERK通路)，又能促进转移(通过调控EMT)，具有双重功能。
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建议通过PubMed或Google Scholar以"DUSP14 antibody"或"DUSP14 function"为关键词查找最新文献，并关注高影响力期刊(如《Nature Immunology》《Cell Reports》等)。
The DUSP14 antibody is a crucial tool in studying the dual-specificity phosphatase 14 (DUSP14), a member of the protein tyrosine phosphatase (PTP) family. DUSP14. also known as MKP6 or TEP, is a dual-specificity phosphatase that dephosphorylates both tyrosine and serine/threonine residues on mitogen-activated protein kinases (MAPKs), particularly JNK and p38. It plays a regulatory role in immune responses, cell proliferation, and apoptosis by modulating MAPK signaling pathways. DUSP14 is highly expressed in immune cells, including T cells and macrophages, and is implicated in inflammatory diseases, autoimmune disorders, and cancer progression.
The DUSP14 antibody is widely used in research to detect protein expression, localization, and activity in various biological samples. It aids in understanding DUSP14’s interaction with substrates, its role in signaling cascades, and its impact on disease mechanisms. Applications include Western blotting, immunohistochemistry, and flow cytometry. Researchers also utilize this antibody to explore DUSP14’s therapeutic potential, as its dysregulation correlates with conditions like rheumatoid arthritis, colitis, and hepatocellular carcinoma.
Validated for specificity and sensitivity, the antibody typically targets conserved epitopes in human, mouse, or rat DUSP14. Studies using knockout models or RNA interference further confirm its reliability. By enabling precise detection, the DUSP14 antibody supports advancements in immunology, oncology, and drug development, offering insights into targeted therapies for MAPK-related pathologies.
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