| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | YVH1; DUSP1 |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DUSP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP12抗体的3篇参考文献示例(注：以下为模拟内容，实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *DUSP12 regulates hepatocellular carcinoma progression through MAPK signaling pathway*
**作者**: Li, X., Zhang, Y., & Wang, H.
**摘要**: 本研究利用DUSP12特异性抗体进行Western blot和免疫组化分析，发现DUSP12在肝癌组织中高表达，并通过调控MAPK信号通路促进肿瘤细胞增殖和转移。
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2. **文献名称**: *DUSP12 modulates inflammatory responses in macrophages via dephosphorylation of p38*
**作者**: Chen, L., et al.
**摘要**: 通过免疫共沉淀和流式细胞术结合DUSP12抗体，研究揭示了DUSP12在巨噬细胞中通过去磷酸化p38蛋白抑制炎症因子释放的分子机制。
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3. **文献名称**: *Characterization of DUSP12 knockout mice reveals its role in glucose metabolism*
**作者**: Park, S., et al.
**摘要**: 研究利用DUSP12抗体检测基因敲除小鼠组织中蛋白表达缺失，发现DUSP12缺失导致胰岛素信号通路异常，提示其可能在糖尿病代谢调控中起关键作用。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“DUSP12 antibody”或“DUSP12 function”获取最新研究。
The DUSP12 antibody is a crucial tool for studying the dual-specificity phosphatase 12 (DUSP12), a member of the protein tyrosine phosphatase (PTP) family. DUSP12. also known as YVH1. is a non-classical dual-specificity phosphatase that regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both tyrosine and serine/threonine residues. Unlike other DUSPs, DUSP12 lacks a MAPK-binding domain but contains a unique N-terminal domain and a conserved C-terminal catalytic phosphatase domain, suggesting distinct regulatory mechanisms. It is implicated in diverse cellular processes, including cell cycle progression, stress responses, and RNA metabolism, with potential roles in cancer, neurodegeneration, and metabolic disorders.
DUSP12 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to detect protein expression, localization, and interactions. These antibodies help elucidate DUSP12’s tissue-specific _expression (e.g., high levels in liver, kidney, and heart) and its dynamic regulation under physiological or pathological conditions. Research has linked DUSP12 to tumor suppression, viral infection responses, and glucose homeostasis, though its precise mechanisms remain under investigation. Validated antibodies with high specificity are essential, as cross-reactivity with other DUSP family members may complicate interpretation. Overall, DUSP12 antibodies serve as vital reagents for unraveling the enzyme’s functional roles and therapeutic potential.
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