| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | TYP, HVH2, MKP2, MKP-2 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DUSP4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP4抗体的3篇参考文献示例(内容为虚构，仅作格式参考)：
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1. **标题**: *DUSP4 Expression in Triple-Negative Breast Cancer: Prognostic Implications*
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫组化分析DUSP4蛋白在乳腺癌组织中的表达，使用特异性DUSP4抗体(克隆号：XYZ)验证其下调与患者生存率降低的关系，提示DUSP4可能作为潜在治疗靶点。
2. **标题**: *DUSP4 Modulates MAPK Signaling in Colorectal Cancer Chemoresistance*
**作者**: Johnson B, et al.
**摘要**: 利用抗DUSP4抗体(货号：ABC123)进行免疫荧光和流式细胞术，发现结直肠癌中DUSP4高表达通过抑制JNK通路导致化疗耐药，为靶向干预提供依据。
3. **标题**: *DUSP4 Deficiency Exacerbates Inflammatory Responses in Macrophages*
**作者**: Lee C, et al.
**摘要**: 通过敲除小鼠模型结合DUSP4抗体(品牌：BioScience)的Western blot分析，证实DUSP4缺失增强p38磷酸化水平，促进炎症因子释放，揭示其在先天免疫中的调控作用。
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如需真实文献，建议在PubMed或Google Scholar检索关键词“DUSP4 antibody” + 应用场景(如Western blot/IHC)，并筛选方法学部分明确提及抗体的研究。
DUSP4 (dual specificity phosphatase 4), also known as MKP-2. is a member of the dual-specificity phosphatase family that regulates mitogen-activated protein kinase (MAPK) signaling pathways, including ERK, JNK, and p38. It functions by dephosphorylating and inactivating MAPKs, thereby modulating cellular responses to stress, growth factors, and cytokines. DUSP4 is implicated in processes such as cell proliferation, differentiation, apoptosis, and immune regulation. Dysregulation of DUSP4 has been linked to various diseases, including cancer, inflammatory disorders, and neurodegenerative conditions, making it a focus of biomedical research.
The DUSP4 antibody is a critical tool for detecting and quantifying DUSP4 protein expression in experimental settings. It is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific expression, subcellular localization, and dynamic changes under physiological or pathological conditions. Researchers employ this antibody to explore correlations between DUSP4 levels and disease progression, therapeutic responses, or molecular mechanisms. For instance, in cancer studies, reduced DUSP4 expression has been associated with enhanced MAPK signaling and tumor aggressiveness. Commercially available DUSP4 antibodies are typically validated for specificity and sensitivity across species, particularly human and mouse models. Its utility extends to drug discovery, where it helps assess DUSP4-targeted therapeutic strategies aiming to restore MAPK pathway homeostasis.
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