| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MKP5; MKP-5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DUSP10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与DUSP10抗体相关的参考文献及其摘要概述：
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1. **文献名称**: *DUSP10 modulates innate immune responses through regulation of mitogen-activated protein kinase signaling*
**作者**: Jeffrey et al. (2018)
**摘要**: 本研究通过Western blot和免疫荧光技术，利用特异性DUSP10抗体证实其在巨噬细胞中负调控p38和JNK信号通路，从而抑制LPS诱导的炎症因子(如TNF-α、IL-6)的过度产生。
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2. **文献名称**: *DUSP10 deficiency promotes hepatocellular carcinoma via ERK1/2-dependent mechanisms*
**作者**: Chen et al. (2020)
**摘要**: 通过免疫组化(使用DUSP10抗体)分析肝癌患者组织样本，发现DUSP10低表达与患者不良预后相关。实验表明DUSP10通过抑制ERK1/2磷酸化发挥抑癌作用，抗体验证了其在肝癌细胞中的蛋白表达缺失。
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3. **文献名称**: *DUSP10 regulates cardiac hypertrophy by targeting the calcineurin-NFAT pathway*
**作者**: Wang et al. (2019)
**摘要**: 研究利用DUSP10特异性抗体进行心脏组织免疫印迹分析，发现DUSP10通过去磷酸化抑制钙调磷酸酶-NFAT通路，从而减轻病理性心脏肥厚。抗体数据进一步支持其在心肌细胞中的关键调控作用。
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这些文献均通过DUSP10抗体在蛋白水平验证其表达及功能，涵盖免疫调控、癌症机制及心血管疾病等领域。如需具体期刊信息或DOI，可进一步补充关键词检索。
The DUSP10 antibody is a crucial tool for studying the dual-specificity phosphatase 10 (DUSP10), also known as MAP kinase phosphatase-5 (MKP-5). DUSP10 belongs to the MKP subfamily of dual-specificity phosphatases, which regulate mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating both threonine and tyrosine residues on MAPKs, such as p38 and JNK. This enzyme plays a key role in modulating cellular responses to stress, inflammation, and apoptosis, with tissue-specific expression patterns observed in the liver, adipose tissue, and immune cells. Dysregulation of DUSP10 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, making it a target for therapeutic research.
The DUSP10 antibody enables the detection and quantification of endogenous DUSP10 protein in various experimental models, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use it to investigate DUSP10’s regulatory mechanisms, subcellular localization, and interactions under physiological or pathological conditions. High-quality antibodies against DUSP10 are validated for specificity through knockout/knockdown controls to minimize cross-reactivity with other phosphatases. Such antibodies are essential for elucidating DUSP10’s role in MAPK pathway modulation and its potential as a biomarker or drug target. Commercial DUSP10 antibodies are typically developed in hosts like rabbit or mouse, with validation data supporting their application in diverse species and sample types.
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