| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HD6; JM21; CPBHM |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human HDAC6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HDAC6抗体的3篇代表性文献，包含名称、作者及摘要概括：
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1. **文献名称**：HDAC6. at the crossroads between cytoskeleton dynamics and cell signaling
**作者**：Boyault C. et al.
**摘要**：该研究揭示了HDAC6作为主要细胞质去乙酰化酶的功能，通过调节α-tubulin的乙酰化状态调控微管稳定性及细胞运动。文中使用特异性HDAC6抗体证实其在细胞质定位，并证明其与分子伴侣蛋白HSP90的相互作用，影响错误折叠蛋白的降解途径。
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2. **文献名称**：HDAC6-selective inhibitors: A tool to decipher the biological roles of HDAC6 in disease models
**作者**：Simoes-Pires C. et al.
**摘要**：研究开发了HDAC6选择性小分子抑制剂，并通过HDAC6抗体验证其在神经退行性疾病模型中的作用。结果显示抑制HDAC6可增强微管稳定性并减少tau蛋白聚集，提示其作为阿尔茨海默病潜在治疗靶点。
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3. **文献名称**：HDAC6 modulates cell motility by altering the acetylation level of cortactin
**作者**：Zhang Y. et al.
**摘要**：该研究利用HDAC6抗体敲低实验，证明HDAC6通过去乙酰化细胞骨架蛋白cortactin调控肿瘤细胞迁移和侵袭能力。机制涉及EGFR信号通路，为HDAC6在癌症转移中的作用提供了新证据。
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4. **文献名称**：HDAC6 regulates antigen-specific immune responses through modulation of tubulin dynamics
**作者**：Seidel C. et al.
**摘要**：通过HDAC6抗体介导的功能抑制实验，发现HDAC6通过调控微管网络影响T细胞受体信号传导及免疫突触形成，揭示其在适应性免疫应答中的关键作用。
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这些文献涵盖了HDAC6在细胞骨架调控、疾病模型及免疫调节中的功能研究，均涉及HDAC6抗体的实验应用。
HDAC6 (histone deacetylase 6) is a unique member of the histone deacetylase family, primarily localized in the cytoplasm rather than the nucleus. Unlike other HDACs, it predominantly targets non-histone substrates, including α-tubulin, HSP90. and cortactin, regulating processes like cell motility, protein degradation, and stress response. HDAC6 contains two functional catalytic domains and a zinc finger ubiquitin-binding domain, enabling its role in aggresome formation and autophagy. Its involvement in critical pathways has linked it to various diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and inflammatory conditions.
HDAC6 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate HDAC6’s interaction with substrates or its dysregulation in disease models. Specificity is crucial due to structural similarities among HDAC family members, and validation via knockout controls or peptide blocking is often required. Recent research focuses on HDAC6 inhibitors as therapeutic agents, driving demand for reliable antibodies to assess target engagement and biomarker efficacy. As HDAC6 gains attention in drug development, its antibodies remain pivotal for both basic research and translational applications.
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