| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MKBP; HSP27; Hs.78846; LOH11CR1K |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSPB2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HSPB2抗体的3篇参考文献及其摘要概述：
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1. **文献名称**: *Differential expression and localization of heat shock proteins HSPB1 and HSPB2 in the myocardium*
**作者**: Golenhofen, N. et al.
**摘要**: 研究通过免疫组化和Western blot分析HSPB2在心肌细胞中的表达，发现其与HSPB1共定位，且在缺血再灌注损伤中表达上调，提示其在心肌保护中的作用。
2. **文献名称**: *HSPB2 expression in skeletal muscle: Implications for muscular dystrophy*
**作者**: Kappe, G. et al.
**摘要**: 通过HSPB2特异性抗体检测其在骨骼肌中的分布，发现其与肌动蛋白细胞骨架相互作用，可能参与维持肌肉结构完整性，并与某些肌营养不良症相关。
3. **文献名称**: *HSPB2 as a biomarker in neurodegenerative disorders*
**作者**: Wilhelmus, M.M. et al.
**摘要**: 研究利用HSPB2抗体分析阿尔茨海默病患者脑组织，发现其与异常tau蛋白共沉积，提示HSPB2可能在神经退行性病变中具有病理调节功能。
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以上文献涵盖了HSPB2在心脏、肌肉及神经系统中的功能研究，均通过特异性抗体揭示其表达模式及潜在病理机制。如需具体文献来源，建议通过PubMed或Google Scholar检索标题或作者名获取全文。
HSPB2. also known as heat shock protein beta-2. is a member of the small heat shock protein (sHSP) family. These proteins function as molecular chaperones, assisting in protein folding, preventing aggregation under stress, and maintaining cellular homeostasis. HSPB2 is structurally characterized by a conserved α-crystallin domain and shares homology with other sHSPs like HSPB1 (HSP27). It is expressed in various tissues, with higher levels observed in skeletal and cardiac muscle, suggesting a role in muscle-specific stress responses.
HSPB2 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate HSPB2's involvement in physiological and pathological processes. Research indicates HSPB2 participates in cellular responses to oxidative stress, ischemia-reperfusion injury, and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Its interaction with other chaperones, such as HSPB1. and its potential role in modulating protein aggregation have sparked interest in therapeutic applications.
Antibody specificity remains a critical consideration, as cross-reactivity with homologous sHSPs can occur. Recent studies also explore HSPB2's biomarker potential in muscle-related disorders. Despite progress, its precise mechanisms and regulatory pathways require further elucidation, driving ongoing demand for reliable HSPB2 antibodies in biomedical research.
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