| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PSGD |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HOXB13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXB13抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**：*HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing prostate from colorectal adenocarcinoma*
**作者**：Varinot J, et al.
**摘要**：该研究验证了HOXB13抗体在前列腺组织中的特异性表达，证明其可作为前列腺癌(尤其是腺癌)的敏感标志物。通过免疫组化分析，发现HOXB13在正常前列腺基底细胞和癌变细胞中高表达，而在结直肠癌等非前列腺组织中几乎不表达，支持其用于鉴别诊断。
2. **文献名称**：*HOXB13 expression in colorectal cancer and its relationship with tumor differentiation*
**作者**：Kryvenko ON, et al.
**摘要**：研究探讨了HOXB13抗体在结直肠癌中的表达模式及其临床意义。结果显示，HOXB13在部分结直肠癌中异常表达，可能与肿瘤分化程度相关，但表达水平显著低于前列腺癌，提示其在鉴别前列腺癌转移至肠道时的潜在价值。
3. **文献名称**：*HOXB13 mutations and hereditary prostate cancer: a functional and immunohistochemical study*
**作者**：Ewing CM, et al.
**摘要**：该文献通过免疫组化结合基因测序，分析了HOXB13突变(如G84E)与遗传性前列腺癌的关系。研究发现，携带突变的患者肿瘤组织中HOXB13蛋白表达异常，提示其在前列腺癌遗传易感性和分子分型中的作用，抗体检测可作为辅助诊断工具。
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**备注**：上述文献为示例，实际引用时建议通过PubMed或Web of Science核对原文信息。若需更多文献，可进一步限定研究领域(如抗体开发、特定癌症类型等)。
The HOXB13 antibody is a valuable tool in biomedical research, particularly in studying the role of the HOXB13 protein, a member of the homeobox (HOX) transcription factor family. HOX genes are critical in embryonic development, regulating body patterning and tissue differentiation. HOXB13. located on chromosome 17q21. is specifically implicated in posterior development, including the prostate, colon, and rectum. Its expression persists in certain adult tissues, where it regulates cell proliferation, differentiation, and apoptosis.
HOXB13 gained prominence due to its link to hereditary prostate cancer. Germline mutations in HOXB13 (e.g., G84E) are associated with increased prostate cancer risk. The antibody is widely used in immunohistochemistry (IHC) to detect HOXB13 protein expression in tumor tissues, aiding in cancer subtyping and prognosis. For instance, HOXB13 is a sensitive marker for prostatic adenocarcinoma, helping distinguish it from carcinomas of other origins.
Researchers also utilize HOXB13 antibodies to explore its regulatory roles in androgen receptor (AR) signaling and interactions with tumor suppressors like CDKN1B. Commercial HOXB13 antibodies (e.g., clone SP348) are validated for specificity in applications like Western blot, IHC, and immunofluorescence. Challenges include optimizing protocols to address cross-reactivity with other HOX proteins. Overall, HOXB13 antibodies are essential for unraveling developmental biology mechanisms and advancing cancer diagnostics and therapeutics.
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