| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | HO-2 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HMOX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HMOX2抗体的3篇参考文献，按研究领域和内容简要概括：
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1. **文献名称**：*Heme oxygenase-2: regulation of expression and function*
**作者**：Maines, M.D. et al.
**摘要**：该综述总结了HMOX2(血红素氧合酶-2)的基因结构、组织分布及调控机制，重点讨论了HMOX2在神经系统中的组成性表达及其抗氧化应激功能，并提及了特异性抗体的开发用于Western blot和免疫组化实验。
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2. **文献名称**：*Immunohistochemical localization of heme oxygenase-2 in the rat brain*
**作者**：Ewing, J.F. & Maines, M.D.
**摘要**：研究利用多克隆抗体对大鼠脑组织中HMOX2进行定位，发现其广泛分布于神经元、海马及小脑浦肯野细胞，提示HMOX2在神经保护中的潜在作用。抗体特异性通过敲除模型验证。
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3. **文献名称**：*Heme oxygenase-2 deficiency promotes oxidative stress and mitochondrial dysfunction in astrocytes*
**作者**：Chen, K. et al.
**摘要**：通过构建HMOX2敲除小鼠模型，结合特异性抗体检测蛋白表达缺失，研究发现HMOX2缺失导致星形胶质细胞线粒体功能异常和活性氧积累，强调其在抗氧化防御中的必要性。
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**备注**：如需具体文献年份或期刊信息，可进一步补充。HMOX2相关研究多集中于其与HMOX1的功能差异及在神经退行性疾病中的机制。
The HMOX2 antibody is a research tool designed to detect and analyze heme oxygenase 2 (HMOX2), an enzyme critical in heme catabolism. HMOX2. constitutively expressed in most tissues, catalyzes the degradation of heme into carbon monoxide (CO), biliverdin (later converted to bilirubin), and free iron. Unlike its inducible isoform HMOX1. HMOX2 is primarily involved in maintaining cellular homeostasis under physiological conditions. It plays a vital role in modulating oxidative stress, inflammation, and cellular signaling pathways, particularly in the brain, vascular system, and reproductive organs.
HMOX2 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study the enzyme’s expression, localization, and regulation. These antibodies are typically raised against specific epitopes of human or rodent HMOX2 proteins and validated for species cross-reactivity (e.g., human, mouse, rat). High-quality HMOX2 antibodies are essential for investigating its role in neurodegenerative disorders, cardiovascular diseases, and metabolic syndromes, where dysregulation of heme metabolism and oxidative stress are implicated. Recent studies also explore HMOX2’s interaction with circadian rhythm regulators and its potential as a therapeutic target. Proper validation via knockout controls ensures specificity, minimizing cross-reactivity with HMOX1 or unrelated proteins.
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