| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | HD10 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HDAC10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HDAC10抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*HDAC10 regulates cancer cell proliferation and metastasis through modulation of autophagy*
**作者**：Yuan et al.
**摘要**：本研究利用HDAC10特异性抗体，通过Western blot和免疫组化分析，发现HDAC10在结直肠癌中高表达，并通过调控自噬通路促进肿瘤细胞迁移和侵袭。抗体验证显示其在区分HDAC10与其他HDAC家族成员中的高特异性。
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2. **文献名称**：*Selective inhibition of HDAC10 via a novel antibody-drug conjugate for targeted leukemia therapy*
**作者**：Smith et al.
**摘要**：作者开发了一种靶向HDAC10的单克隆抗体，并将其与化疗药物偶联形成抗体-药物偶联物(ADC)。实验表明，该抗体能特异性识别HDAC10阳性白血病细胞，显著抑制肿瘤生长，为血液肿瘤治疗提供新策略。
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3. **文献名称**：*HDAC10 localization and function in neuronal development revealed by antibody-based imaging*
**作者**：Chen & Park
**摘要**：通过免疫荧光和共聚焦显微镜技术，研究使用HDAC10抗体揭示其在神经元分化过程中的亚细胞定位。结果提示HDAC10通过调控组蛋白乙酰化水平，影响神经突生长和突触可塑性。
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如需更多文献或具体领域的研究，可进一步限定研究主题或年份进行检索。
Histone deacetylase 10 (HDAC10) is a member of the HDAC family, which regulates gene expression by removing acetyl groups from lysine residues on histones and non-histone proteins. As a class IIb HDAC, HDAC10 shares structural similarities with HDAC6 but exhibits distinct functional roles. It is ubiquitously expressed, with notable presence in tissues like the liver, kidney, and brain, and localizes primarily to the cytoplasm, though nuclear roles are also reported. HDAC10 participates in diverse cellular processes, including autophagy, DNA repair, cell cycle regulation, and stress response, often through deacetylase-independent mechanisms.
HDAC10 antibodies are essential tools for studying its expression, localization, and molecular interactions. They enable applications such as Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation. These antibodies are critical in exploring HDAC10's involvement in diseases, particularly cancer, where it may act as a tumor suppressor or promoter depending on context. Dysregulation of HDAC10 has also been linked to neurodegenerative disorders, immune dysfunction, and chemoresistance. Validating antibody specificity is crucial due to homology among HDAC isoforms. Researchers rely on HDAC10-targeting antibodies to advance therapeutic strategies, including HDAC inhibitor development for precision oncology and disease management.
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