| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | ST7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LRP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇涉及LRP12抗体的研究文献示例(内容为模拟概括，建议通过学术数据库核实具体文献)：
---
1. **文献名称**: "LRP12 regulates cell migration and invasion via Wnt/β-catenin signaling in colorectal cancer"
**作者**: Smith A, et al.
**摘要**: 本研究利用抗LRP12抗体进行Western blot和免疫组化分析，发现LRP12在结直肠癌组织中高表达，并通过调控Wnt/β-catenin通路促进肿瘤细胞迁移和侵袭。
---
2. **文献名称**: "The role of LRP12 in neuronal differentiation and Alzheimer’s disease pathology"
**作者**: Johnson R, et al.
**摘要**: 通过抗LRP12抗体的免疫荧光染色，作者证实LRP12在小鼠大脑皮层神经元中表达，并发现其与淀粉样蛋白前体蛋白(APP)存在相互作用，可能影响阿尔茨海默病的病理进程。
---
3. **文献名称**: "LRP12 interacts with TGF-β receptors to modulate epithelial-mesenchymal transition"
**作者**: Lee H, et al.
**摘要**: 使用抗LRP12抗体进行免疫共沉淀(Co-IP)实验，揭示了LRP12与TGF-β受体复合物的结合，并通过调控上皮-间质转化(EMT)影响乳腺癌细胞的转移能力。
---
**注意**：以上为示例性内容，实际文献需通过PubMed、Google Scholar或Web of Science等平台检索关键词(如“LRP12 antibody”、“LRP12 function”)获取。如需具体文献，建议补充研究领域或应用场景以便精准筛选。
The LRP12 antibody is a research tool designed to target the low-density lipoprotein receptor-related protein 12 (LRP12), a transmembrane protein belonging to the LDL receptor family. LRP12. also known as ST7R or LRPR1. is implicated in intracellular signaling and membrane trafficking processes, though its precise biological functions remain under investigation. Studies suggest its involvement in regulating receptor-mediated endocytosis, Wnt signaling pathways, and cellular adhesion, with emerging roles in cancer progression, neurological disorders, and metabolic diseases.
Antibodies against LRP12 are commonly used in immunoblotting (WB), immunofluorescence (IF), and immunohistochemistry (IHC) to study its expression, localization, and interactions in various tissues and disease models. Due to LRP12's structural similarity to other LDL receptor family members, antibody specificity is critical, requiring validation via knockout or knockdown controls. Commercial LRP12 antibodies are available from multiple suppliers, often developed using immunogenic peptides corresponding to specific regions of the human or murine protein.
Research utilizing LRP12 antibodies has contributed to identifying its potential as a biomarker in certain cancers and its regulatory role in neuronal development. However, functional studies remain limited, underscoring the need for further characterization of LRP12's mechanisms and therapeutic relevance.
×
